MRNA capping enzyme: Difference between revisions
Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref>... |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
'''mRNA capping enzyme''' (Mce) | '''mRNA capping enzyme''' (Mce) is a multfunctonal protein with RNA triphosphatase, RNA guanylyltransferase, RNA methyltransferase and transcription factor activities activities. Mce activity entails the transfer of GMP from GTP to the 5'-diphosphate end of mRNA via a enzyme-(lysyl-GMP) intermediate. In Vaccinia virus the active site is at Lys260 within the conserved motif KxDG in thencatalytic subunit<ref>PMID:7565775</ref>. | ||
== Disease == | == Disease == | ||