Periplasmic dipeptide-binding protein: Difference between revisions
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== ''M. tuberculosis'' and Iron Uptake == | == ''M. tuberculosis'' and Iron Uptake == | ||
''Mycobacterium tuberculosis'' (Mtb) is a droplet-spread bacteria which causes tuberculosis. The bacterium lives and reproduces within the phagosomes of alveolar macrophages. In 2018 alone, nearly 1.5 million people died from tuberculosis, making it among the top 10 diseases in terms of mortality<ref>“Tuberculosis (TB).” World Health Organization, World Health Organization, | ''Mycobacterium tuberculosis'' (Mtb) is a droplet-spread bacteria which causes tuberculosis. The bacterium lives and reproduces within the phagosomes of alveolar macrophages. In 2018 alone, nearly 1.5 million people died from tuberculosis, making it among the top 10 diseases in terms of mortality<ref>“Tuberculosis (TB).” World Health Organization, World Health Organization, | ||
www.who.int/news-room/fact-sheets/detail/tuberculosis.</ref>. Being that iron is relatively scarce within alveolar macrophage phagosomes, Mtb has evolved intricate means by which iron is uptaken. The sheer number of genes dedicated to these processes is an indication of the complex evolution of this uptake. For instance, | www.who.int/news-room/fact-sheets/detail/tuberculosis.</ref>. Being that iron is relatively scarce within alveolar macrophage phagosomes, Mtb has evolved intricate means by which iron is uptaken. The sheer number of genes dedicated to these processes is an indication of the complex evolution of this uptake. For instance, approximately 35 known genes in the Mtb genome are associated only with the production of salicylate-derivative iron siderophores termed mycobactins<ref>DOI: 10.1086/518040</ref>. | ||
== Heme Transport Into Mtb == | == Heme Transport Into Mtb == | ||