User:Caleb Holaway/Sandbox 1: Difference between revisions

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== Background ==

Pathogenic bacteria requirem several metal cofactors for enzymatic activity and, therein, performance of biochemical processes. As a result, these parasites have evolved mechanisms by which they can uptake essential nutrients from their host. Though many of these ions are present in the cytosol of host cells or in the extracellular matrix of host tissue at various concentrations, thereby making sequestering these materials relatively simple, iron presents an interesting obstacle in terms of accessibility for bacteria in that it exists mainly in erythrocytes in the heme compound hemoglobin, though it also exists in storage compounds such as ferritin, lactoferrin, transferrin, and hemosiderin(***ref ~~4***)~~. As a result, pathogens have evolved several means by which heme and hemoglobin can be uptaken by cells and degraded for abstraction of iron.

Pathogenic bacteria requirem several metal cofactors for enzymatic activity and, therein, performance of biochemical processes. As a result, these parasites have evolved mechanisms by which they can uptake essential nutrients from their host. Though many of these ions are present in the cytosol of host cells or in the extracellular matrix of host tissue at various concentrations, thereby making sequestering these materials relatively simple, iron presents an interesting obstacle in terms of accessibility for bacteria in that it exists mainly in erythrocytes in the heme compound hemoglobin, though it also exists in storage compounds such as ferritin, lactoferrin, transferrin, and hemosiderin<ref>Ems, Thomas. “Biochemistry, Iron Absorption.” StatPearls [Internet]., U.S. National Library of

Medicine, 21 Apr. 2019, www.ncbi.nlm.nih.gov/books/NBK448204/.</ref>. As a result, pathogens have evolved several means by which heme and hemoglobin can be uptaken by cells and degraded for abstraction of iron.

== M. Tuberculosis and Iron Uptake ==

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 == Background ==
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-Pathogenic bacteria requirem several metal cofactors for enzymatic activity and, therein, performance of biochemical processes. As a result, these parasites have evolved mechanisms by which they can uptake essential nutrients from their host.  Though many of these ions are present in the cytosol of host cells or in the extracellular matrix of host tissue at various concentrations, thereby making sequestering these materials relatively simple, iron presents an interesting obstacle in terms of accessibility for bacteria in that it exists mainly in erythrocytes in the heme compound hemoglobin, though it also exists in storage compounds such as ferritin, lactoferrin, transferrin, and hemosiderin(***ref 4***). As a result, pathogens have evolved several means by which heme and hemoglobin can be uptaken by cells and degraded for abstraction of iron.
+Pathogenic bacteria requirem several metal cofactors for enzymatic activity and, therein, performance of biochemical processes. As a result, these parasites have evolved mechanisms by which they can uptake essential nutrients from their host.  Though many of these ions are present in the cytosol of host cells or in the extracellular matrix of host tissue at various concentrations, thereby making sequestering these materials relatively simple, iron presents an interesting obstacle in terms of accessibility for bacteria in that it exists mainly in erythrocytes in the heme compound hemoglobin, though it also exists in storage compounds such as ferritin, lactoferrin, transferrin, and hemosiderin<ref>Ems, Thomas. “Biochemistry, Iron Absorption.” StatPearls [Internet]., U.S. National Library of
+Medicine, 21 Apr. 2019, www.ncbi.nlm.nih.gov/books/NBK448204/.</ref>. As a result, pathogens have evolved several means by which heme and hemoglobin can be uptaken by cells and degraded for abstraction of iron.
 == M. Tuberculosis and Iron Uptake ==