Sandbox Reserved 1625: Difference between revisions

Another significant structural feature of bd oxidase is the <scene name='83/832924/Q_loop/3'>Q-loop</scene> which is located between TM helices 6 and 7 of the CydA subunit.<ref name="Alexander">PMID:31723136</ref> The periplasmic Q-loop in ''E. coli'' stretches over a length of 136 amino acid residues, making it much longer than the Q-loop in [https://en.wikipedia.org/wiki/Geobacillus_thermoglucosidasius ''Geobacillus Thermodenitrificans''].<ref name="Safarian">PMID: 27126043</ref> With five helices acting as a flap covering heme b595, the Q-loop is likely involved in [https://en.wikipedia.org/wiki/Hydroquinone quinol] binding and oxidation. The [https://en.wikipedia.org/wiki/N-terminus N-terminal end] of this Q-loop is very flexible and likely functions as the hinge that allows for quinone binding while the [https://en.wikipedia.org/wiki/C-terminus C-terminal end] is much more rigid which provides stabilization for the enzyme.<ref name="Alexander">PMID:31723136</ref>