Virus protease 3D structures

3D Structures of Virus proteases3D Structures of Virus proteases

Updated on 15-April-2020

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• HIV-1 protease . See Immunodeficiency virus protease
• HIV-2 protease See Immunodeficiency virus protease
• Feline Immunodeficiency virus protease See Immunodeficiency virus protease

• Simian Immunodeficiency virus protease See Immunodeficiency virus protease
• Xenotropic murine leukemia virus protease
  • 3nr6 – XMRV-PR P14
    
  • 3p1g – XMRV-PR RNase H domain (mutant)
    
  • 3slz – XMRV-PR residues 533-657 + inhibitor
    
  • 3sm1 – XMRV-PR residues 533-657 + pepstatin
    
  • 3sm2 – XMRV-PR residues 533-657 + amprenavir
    
• Human T-cell leukemia virus protease
  • 2b7f – HTLV-PV + peptide
    
  • 3lin, 3liq, 3lit, 3liv, 3lix, 3liy, 4ydg, 4ydf – HTLV-PV (mutant) + inhibitor
    
• Rous sarcoma virus protease
  • 2rsp – RSVP - Rous sarcoma virus
    
  • 1bai – RSVP + polypeptide inhibitor
• Human Cytomegalovirus protease
  • 1wpo – CMVP - human herpes virus 5
    
  • 1cmv, 1lay, 1jq6, 1id4, 1iec, 1ied, 1ief, 1ieg – CMVP (mutant)
    
  • 2wpo, 1jq7 - CMVP (mutant) + inhibitor
    
  • 1njt, 1nju, 1nkk, 1nkm - CMVP (mutant) + peptide inhibitor
    
• Varicella-Zoster virus protease
  • 1vzv - VZVP (mutant) – human herpes virus
• Equine infectious anemia virus protease
  • 2fmb, 1fmb – EIAVP (mutant) + inhibitor
• Hepatitis A virus protease
  • 1hav – HAVP (mutant) – hepatitis A virus
    
  • 2h9h, 2hal – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
    
  • 2h6m – HAVP + peptide inhibitor
    
  • 1qa7, 3r0f – HAVP (mutant) + inhibitor
    
• Hepatitis C virus protease
  • 2o8m – HCVP (mutant)
    
  • 2a4g, 2gvf, 2f9u, 2f9v – HCVP + peptide inhibitor
    
  • 6nzt, 6nzv, 6piu, 6piv, 6piw, 6pix, 6piy, 6piz, 6pj0, 6pj1, 6pj2 – HCVP (mutant) + inhibitor
    
• Orf 17
  • 3njq – hOrf 17 - human herpes virus 8
• Dengue virus protease
  • 3u1i – DvNs2b + peptide – Dengue virus
    
  • 3u1j – DvNs2b + BPTI
    
  • 2fom - DvNs2b/DvNs3
    
  • 4m9f, 4m9i, 4m9k, 4m9m, 3lkw - DvNs2b/DvNs3 (mutant)
    
  • 6mo0, 6mo1, 6mo2 - DvNs2b residues 1394-1440 + inhibitor
    
  • 4m9t - DvNs2b/DvNs3 (mutant) + inhibitor
    
  • 2jlq – DvNs3 residues 1646-2092
    
  • 2jlv – DvNs3 residues 1646-2092 + AMPPNP + RNA
    
  • 2jlr – DvNs3 residues 1646-2092 + AMPPNP
    
  • 2jls – DvNs3 residues 1646-2092 + ADP
    
  • 2jlx, 2jly, 2jlz – DvNs3 residues 1646-2092 + ADP + RNA
    
  • 2jlu, 2jlw – DvNs3 residues 1646-2092 + RNA
    
  • 2vbc, 2whx, 2wzq – DvNs3 residues 1475-2092 + peptide inhibitor
    
  • 2m9p, 2m9q – DvNs3 residues 1475-1648 + peptide inhibitor - NMR
    
  • 6izy – DvNs5 RNA polymerase domain residues 2742-3387
    
  • 6izx – DvNs5 RNA polymerase domain residues 2742-3387 + inhibitor
    
• Herpes simplex virus protease
  • 1at3 – HSV II – human herpesvirus 2
• Foot-and-Mouth Disease virus protease
  • 2bhg – FMDV residues 1650-1857 (mutant) – Foot-and-mouth disease virus
    
  • 2jqf, 2j92, 5hm2 – FMDV (mutant)
    
  • 2wv4, 2wv5 – FMDV (mutant) + peptide
    
• Infectious Bronchitis virus protease
  • 2q6d, 4x2z – IBV – infectious bronchitis virus
    
  • 2q6f – IBV + inhibitor
• Yellowtail ascites virus protease
  • 4cx8, 4b07, 4b0t – YAV – yellowtail ascites virus
    
  • 4b08 – YAV + inhibitor
    
  • 4izj, 4izk – YAV Vp4 (mutant)
• Yellow fever virus protease
  • 6urv – NS2B + NS3
    
• Zika virus protease
  • 6um3, 6jpw – NS2B + NS3
    
• Pseudorabies virus protease
  • 4cx8 – YAV – pseudorabies virus
    
• Coxsakievirus protease
  • 2vb0, 2zty, 2ztz, 3zyd, 3sj8 – CSVP
    
  • 2zu1, 3zye, 3zz3, 3zz4 – CSVP (mutant)
    
  • 2ztx – CSVP + Zn-H2S
    
  • 2zu3, 3zz5, 3zz6, 3zz7, 3zz8, 3zz9, 3zza, 3zzb, 3sji – CSVP + inhibitor
    
  • 3zzc, 3zzd – CSVP (mutant) + inhibitor
    
  • 3sj9 – CSVP (mutant) + peptide inhibitor
    
• Human polio virus protease
  • 1l1n – HPV
    
  • 2ijd – HPV (mutant)
    
• Human rhinovirus protease
  • 2in2 – HRVP – human rhinovirus - NMR
    
  • 1cqq, 2xya, 5fx5, 5fx6, 6ffn, 6ffs – HRVP + inhibitor
    
  • 2b0f – HRVP + inhibitor – NMR
    
  • 2h6m – HRVP + peptide inhibitor
    
• Human enterovirus protease
  • 3osy – HEVP 71 – human enterovirus
    
  • 3zv8 – HEVP 68 residues 1549-1731
    
  • 3q3x – HEVP B (mutant)
    
  • 3q3y – HEVP B (mutant) + inhibitor
    
  • 3ruo – HEVP B + inhibitor
    
  • 3sjk – HEVP 71 (mutant) + peptide inhibitor
    
  • 3sjo, 5bpe, 5hxf, 5wq2 – HEVP 71 + inhibitor
    
  • 3qzq, 3qzr – HEVP 71 (mutant) + inhibitor
    
  • 3zv9, 3zva, 3zvb, 3zvc, 3zvd, 3zve, 3zvf, 3zvg – HEVP 68 + inhibitor
    
• Porcine epidemic diarrhea virus protease
  • 5hyo, 6noz – PEDVP – porcine epidemic diarrhea virus
    
• Coronavirus protease
  • 4wme, 4wmf – CVP (mutant)- coronavirus
    
• SARS coronavirus protease
  • 3e91, 3ea7, 3ea8, 3ea9, 3eaj – SCVP (mutant) – SARS coronavirus
    
  • 2amd, 2amq, 2gx4, 2z9g, 2z9j, 2z9k, 2z9l, 2zu5, 4mds, 4tww, 4twy – SCVP + inhibitor
    
• SARS CoV-2 protease
  • 6y84 – COV-19
    
  • 6lu7 – COV-19 + inhibitor
    
• Murine coronavirus protease
  • 6jij – MCP + peptide inhibitor
    
• Coronavirus HKU4 protease
  • 2ynb – CVHP + inhibitor – BAT coronavirus
    
• Echovirus 1 protease
  • 5iyt – EV1P (mutant) + inhibitor – Echovirus 1
    
• Norovirus protease
  • 5e0g, 5e0h, 5e0j – NVP (mutant)+ peptide inhibitor – Norovirus
    
  • 3ur9, 4imq, 4xbb, 4xbc, 4xbd, 5dg6, 5dgj, 5tg1, 5tg2 – NVP residues 1101-1281 + inhibitor
    
• Norovirus 3C-like protease
  • 1wqs – NVLP – chiba virus
    
• Gastroentritis virus protease
  • 2amp – GEVP + inhibitor – gastroenteritis virus
    
• Southampton virus protease
  • 2iph – SVP + inhibitor – Southampton virus
    
• West Nile virus protease
  • 2ggv - WNVP (mutant) - West Nile virus
    
  • 2ijo - WNVP (mutant) + BPTI
    
  • 2yol, 5idk, 2fp7 - WNVP + peptide inhibitor
    
  • 3e90 - WNVP + inhibitor
    
• African swine fever virus protease
  • 6ljb, 6lj9 – ASFV – African swine fever virus