5e0r: Difference between revisions

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==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
==Crystal Structure of the first bromodomain of BRD4 in complex with AYC==
<StructureSection load='5e0r' size='340' side='right' caption='[[5e0r]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='5e0r' size='340' side='right'caption='[[5e0r]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
<table><tr><td colspan='2'>[[5e0r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E0R OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E0R FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5J5:2-[(CHLOROACETYL)AMINO]-5-[(E)-(4-SULFOPHENYL)DIAZENYL]BENZENESULFONIC+ACID'>5J5</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e0r OCA], [http://pdbe.org/5e0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e0r RCSB], [http://www.ebi.ac.uk/pdbsum/5e0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e0r ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).  
==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
[[Category: Dong, J]]
[[Category: Dong, J]]
[[Category: Transcription-transcription inhibitor complex]]
[[Category: Transcription-transcription inhibitor complex]]

Revision as of 11:16, 15 April 2020

Crystal Structure of the first bromodomain of BRD4 in complex with AYCCrystal Structure of the first bromodomain of BRD4 in complex with AYC

Structural highlights

5e0r is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:BRD4, HUNK1 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

See Also

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

5e0r, resolution 1.35Å

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