Glucagon-like peptide 1 receptor: Difference between revisions
Michal Harel (talk | contribs) New page: ==Your Heading Here (maybe something like 'Structure')== <ref>PMID:21638687</ref> to the rescue. == Function == '''Glucagon-like peptide 1 receptor''' (GLP-1R) == Disease == == Relevan... |
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== Function == | == Function == | ||
'''Glucagon-like peptide 1 receptor''' (GLP-1R) | '''Glucagon-like peptide 1 receptor''' (GLP-1R) mediates the action of glucagon-like peptides (GLP-1) which are hormones involved in nutrient intake, gastrointestinal motility, islet hormone secretion, cell proliferation and apoptpsis<ref>PMID:12529935</ref>. | ||
== | == Relevance == | ||
GLP-1R agonists are used in treatment of type 2 diabetes<ref>PMID:21950636</ref>. GLP-1 analogues can cross the brain-blood barrier and stimulate the GLP-1R in the brain. This stimulation is affecting mitochondrial functioning, protein aggregation, neuroinflammation, synaptic plasticity, learning and memory in models of Parkinson Disease and Alzheimer Disease<ref>PMID:26851597</ref>. | |||
== Structural highlights == | == Structural highlights == | ||