6raz: Difference between revisions

<table><tr><td colspan='2'>[[6raz]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RAZ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6raz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6raz OCA], [http://pdbe.org/6raz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6raz RCSB], [http://www.ebi.ac.uk/pdbsum/6raz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6raz ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/MCM3_DROME MCM3_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16798881</ref> <ref>PMID:20122406</ref>  [[http://www.uniprot.org/uniprot/Q9VBI1_DROME Q9VBI1_DROME]] The GINS complex plays an essential role in the initiation of DNA replication.[PIRNR:PIRNR007764] [[http://www.uniprot.org/uniprot/MCM5_DROME MCM5_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16798881</ref> <ref>PMID:20122406</ref>  [[http://www.uniprot.org/uniprot/MCM4_DROME MCM4_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. Essential role in mitotic DNA replication but not in endoreplication.<ref>PMID:16798881</ref> <ref>PMID:20122406</ref>  [[http://www.uniprot.org/uniprot/MCM2_DROME MCM2_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.<ref>PMID:16798881</ref> <ref>PMID:20122406</ref> <ref>PMID:7622035</ref>  [[http://www.uniprot.org/uniprot/MCM7_DROME MCM7_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.<ref>PMID:16798881</ref> <ref>PMID:20122406</ref>  [[http://www.uniprot.org/uniprot/MCM6_DROME MCM6_DROME]] Acts as component of the Mcm2-7 complex (Mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the Mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity Required for DNA replication and cell proliferation. Required for mitotic cycles, endocycles, and the special S phase associated with the amplification of chorion genes; has a role in origin unwinding or fork elongation at chorion loci.<ref>PMID:11854416</ref> <ref>PMID:16798881</ref> <ref>PMID:20122406</ref>  [[http://www.uniprot.org/uniprot/PSF2_DROME PSF2_DROME]] The GINS complex plays an essential role in the initiation of DNA replication.