1zku

Fitting of the gp9 structure in the EM density of bacteriophage T4 extended tailFitting of the gp9 structure in the EM density of bacteriophage T4 extended tail

1zku, resolution 15.00Å Show:Asymmetric Unit Biological Assembly Structural highlights 1zku is a 18 chain structure with sequence from Bpt4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Related: 1qex, 1s2e, 1pdl Gene: 9 (BPT4) Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [VG09_BPT4] Structural component of the baseplate. Connects the long tail fibers to the baseplate and triggers the tail contraction after virus attachment to a host cell. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Bacteriophage T4 and related viruses have a contractile tail that serves as an efficient mechanical device for infecting bacteria. A three-dimensional cryo-EM reconstruction of the mature T4 tail assembly at 15-A resolution shows the hexagonal dome-shaped baseplate, the extended contractile sheath, the long tail fibers attached to the baseplate and the collar formed by six whiskers that interact with the long tail fibers. Comparison with the structure of the contracted tail shows that tail contraction is associated with a substantial rearrangement of the domains within the sheath protein and results in shortening of the sheath to about one-third of its original length. During contraction, the tail tube extends beneath the baseplate by about one-half of its total length and rotates by 345 degrees , allowing it to cross the host's periplasmic space. The tail structure of bacteriophage T4 and its mechanism of contraction.,Kostyuchenko VA, Chipman PR, Leiman PG, Arisaka F, Mesyanzhinov VV, Rossmann MG Nat Struct Mol Biol. 2005 Sep;12(9):810-3. Epub 2005 Aug 14. PMID:16116440 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.