Spike protein: Difference between revisions
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== Function == | == Function == | ||
The viral '''spike protein''' (Spi) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus. | The viral '''spike protein''' (Spi) binds the virus to its host cell via the cell's receptor: angiotensin-converting enzyme 2 (ACE2). The trimeric 2019-nCoV Spi binds to ACE2 at least 10 times more tightly than SARS coronavirus Spi. | ||
== Disease == | == Disease == | ||
Numerous viral diseases are causing world-shattering consequences and the current pandemic CoVID-2019 is the recent one. | Numerous viral diseases are causing world-shattering consequences and the current pandemic of CoVID-2019 is the recent one. | ||
== Relevance == | == Relevance == | ||
The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential antiviral treatment<ref>PMID:32065055</ref>. | The spike protein is a key target for potential therapies and diagnostics. Various antibodies are currently being tested as potential CoVID-2019 antiviral treatment<ref>PMID:32065055</ref>. | ||
== Structural highlights == | == Structural highlights == | ||