1ay2: Difference between revisions

Revision as of 10:49, 2 May 2008

STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION

OverviewOverview

The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multifunctional pilus adhesion and virulence factor, reveals an alpha-beta roll fold with a striking 85 A alpha-helical spine and an O-linked disaccharide. Key residues stabilize interactions that allow sequence hypervariability, responsible for pilin's celebrated antigenic variation, within disulphide region beta-strands and connections. Pilin surface shape, hydrophobicity and sequence variation constrain pilus assembly to the packing of flat subunit faces against alpha 1 helices. Helical fibre assembly is postulated to form a core of coiled alpha 1 helices banded by beta-sheet, leaving carbohydrate and hypervariable sequence regions exposed to solvent.

About this StructureAbout this Structure

1AY2 is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the fibre-forming protein pilin at 2.6 A resolution., Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA, Nature. 1995 Nov 2;378(6552):32-8. PMID:7477282 Page seeded by OCA on Fri May 2 10:49:50 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1ay2.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1ay2 |SIZE=350|CAPTION= <scene name='initialview01'>1ay2</scene>, resolution 2.6&Aring;
+The line below this paragraph, containing "STRUCTURE_1ay2", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=CH3:METHYL+GROUP'>CH3</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1ay2|  PDB=1ay2  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ay2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ay2 OCA], [http://www.ebi.ac.uk/pdbsum/1ay2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ay2 RCSB]</span>
-}}
 '''STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION'''
@@ Line 28: / Line 25: @@
 [[Category: Parge, H E.]]
 [[Category: Tainer, J A.]]
-[[Category: fiber-forming protein]]
+[[Category: Fiber-forming protein]]
-[[Category: glycoprotein]]
+[[Category: Glycoprotein]]
-[[Category: saccharide]]
+[[Category: Saccharide]]
-[[Category: type 4 pilin]]
+[[Category: Type 4 pilin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:49:50 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:49:46 2008''