5d13: Difference between revisions

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==Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide==
==Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide==
<StructureSection load='5d13' size='340' side='right' caption='[[5d13]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='5d13' size='340' side='right'caption='[[5d13]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5d13]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D13 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5d13]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D13 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56J:3-(9H-FLUOREN-9-YL)PROPANAL'>56J</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=56J:3-(9H-FLUOREN-9-YL)PROPANAL'>56J</scene>, <scene name='pdbligand=LYS:LYSINE'>LYS</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d13 OCA], [http://pdbe.org/5d13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d13 RCSB], [http://www.ebi.ac.uk/pdbsum/5d13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d13 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d13 OCA], [http://pdbe.org/5d13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d13 RCSB], [http://www.ebi.ac.uk/pdbsum/5d13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d13 ProSAT]</span></td></tr>
</table>
</table>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: De, S]]
[[Category: De, S]]
[[Category: Olson, R]]
[[Category: Olson, R]]

Revision as of 13:32, 1 April 2020

Third PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptideThird PDZ domain (PDZ3) of PSD-95 complexed with CFMOC-KKETEV peptide

Structural highlights

5d13 is a 8 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:Dlg4, Dlgh4, Psd95 (Buffalo rat)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.[1] [2]

References

  1. ↑ Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem. 2004 Nov 5;279(45):46962-8. Epub 2004 Aug 17. PMID:15317815 doi:10.1074/jbc.M405874200
  2. ↑ Prange O, Wong TP, Gerrow K, Wang YT, El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13915-20. Epub 2004 Sep 9. PMID:15358863 doi:10.1073/pnas.0405939101

5d13, resolution 2.15Å

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