6hn3: Difference between revisions
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==wildtype form (apo) of human GPX4 with Se-Cys46== | |||
<StructureSection load='6hn3' size='340' side='right'caption='[[6hn3]], [[Resolution|resolution]] 1.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hn3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HN3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HN3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr> | |||
[[Category: | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6hkq|6hkq]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipid-hydroperoxide_glutathione_peroxidase Phospholipid-hydroperoxide glutathione peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.12 1.11.1.12] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hn3 OCA], [http://pdbe.org/6hn3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hn3 RCSB], [http://www.ebi.ac.uk/pdbsum/6hn3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hn3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GPX4_HUMAN GPX4_HUMAN]] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Phospholipid-hydroperoxide glutathione peroxidase]] | |||
[[Category: Badock, V]] | |||
[[Category: Eaton, J K]] | |||
[[Category: Gradl, S]] | |||
[[Category: Hillig, R C]] | |||
[[Category: Hilpmann, A]] | |||
[[Category: Hoffmann, J]] | |||
[[Category: Moosmayer, D]] | |||
[[Category: Schnirch, L]] | |||
[[Category: Anti-oxidatve defense system]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 12:04, 1 April 2020
wildtype form (apo) of human GPX4 with Se-Cys46wildtype form (apo) of human GPX4 with Se-Cys46
Structural highlights
Function[GPX4_HUMAN] Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). |
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