6w2c: Difference between revisions

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'''Unreleased structure'''


The entry 6w2c is ON HOLD
==Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site==
 
<StructureSection load='6w2c' size='340' side='right'caption='[[6w2c]], [[Resolution|resolution]] 6.30&Aring;' scene=''>
Authors: Coleman, J.A., Navratna, V., Yang, D.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6w2c]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6W2C FirstGlance]. <br>
Description: Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=RFY:I-paroxetine'>RFY</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6w2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w2c OCA], [http://pdbe.org/6w2c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6w2c RCSB], [http://www.ebi.ac.uk/pdbsum/6w2c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6w2c ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/SC6A4_HUMAN SC6A4_HUMAN]] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.<ref>PMID:17506858</ref> <ref>PMID:18227069</ref> <ref>PMID:19270731</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Coleman, J A]]
[[Category: Navratna, V]]
[[Category: Yang, D]]
[[Category: Yang, D]]
[[Category: Navratna, V]]
[[Category: Antibody]]
[[Category: Coleman, J.A]]
[[Category: Antidepressant]]
[[Category: Complex]]
[[Category: Transport protein]]
[[Category: Transporter]]

Revision as of 13:25, 27 March 2020

Anomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central siteAnomalous iodine signal reveals the position of I-paroxetine complexed with the serotonin transporter at the central site

Structural highlights

6w2c is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SC6A4_HUMAN] Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.[1] [2] [3]

References

  1. ↑ Brenner B, Harney JT, Ahmed BA, Jeffus BC, Unal R, Mehta JL, Kilic F. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007 Jul;102(1):206-15. Epub 2007 May 15. PMID:17506858 doi:http://dx.doi.org/10.1111/j.1471-4159.2007.04542.x
  2. ↑ Ahmed BA, Jeffus BC, Bukhari SI, Harney JT, Unal R, Lupashin VV, van der Sluijs P, Kilic F. Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter. J Biol Chem. 2008 Apr 4;283(14):9388-98. doi: 10.1074/jbc.M706367200. Epub 2008, Jan 28. PMID:18227069 doi:http://dx.doi.org/10.1074/jbc.M706367200
  3. ↑ Ahmed BA, Bukhari IA, Jeffus BC, Harney JT, Thyparambil S, Ziu E, Fraer M, Rusch NJ, Zimniak P, Lupashin V, Tang D, Kilic F. The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. PLoS One. 2009;4(3):e4730. doi: 10.1371/journal.pone.0004730. Epub 2009 Mar 9. PMID:19270731 doi:http://dx.doi.org/10.1371/journal.pone.0004730

6w2c, resolution 6.30Å

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