2ffh: Difference between revisions
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==THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS== | ==THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS== | ||
<StructureSection load='2ffh' size='340' side='right' caption='[[2ffh]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='2ffh' size='340' side='right'caption='[[2ffh]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ffh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFH FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ffh]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_25104 Atcc 25104]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FFH FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Atcc 25104]] | [[Category: Atcc 25104]] | ||
[[Category: Large Structures]] | |||
[[Category: Freymann, D M]] | [[Category: Freymann, D M]] | ||
[[Category: Keenan, R J]] | [[Category: Keenan, R J]] | ||
Revision as of 13:49, 18 March 2020
THE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUSTHE SIGNAL SEQUENCE BINDING PROTEIN FFH FROM THERMUS AQUATICUS
Structural highlights
Function[SRP54_THEAQ] Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY (By similarity).[HAMAP-Rule:MF_00306] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe crystal structure of the signal sequence binding subunit of the signal recognition particle (SRP) from Thermus aquaticus reveals a deep groove bounded by a flexible loop and lined with side chains of conserved hydrophobic residues. The groove defines a flexible, hydrophobic environment that is likely to contribute to the structural plasticity necessary for SRP to bind signal sequences of different lengths and amino acid sequence. The structure also reveals a helix-turn-helix motif containing an arginine-rich alpha helix that is required for binding to SRP RNA and is implicated in forming the core of an extended RNA binding surface. Crystal structure of the signal sequence binding subunit of the signal recognition particle.,Keenan RJ, Freymann DM, Walter P, Stroud RM Cell. 1998 Jul 24;94(2):181-91. PMID:9695947[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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