6klh: Difference between revisions
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==Dimeric structure of Machupo virus polymerase bound to vRNA promoter== | |||
<StructureSection load='6klh' size='340' side='right'caption='[[6klh]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6klh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KLH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6klh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6klh OCA], [http://pdbe.org/6klh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6klh RCSB], [http://www.ebi.ac.uk/pdbsum/6klh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6klh ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Gao, G F]] | |||
[[Category: Jing, J]] | |||
[[Category: Peng, Q]] | |||
[[Category: Peng, R]] | |||
[[Category: Shi, Y]] | |||
[[Category: Xu, X]] | |||
[[Category: Polymerase]] | |||
[[Category: Rna virus]] | |||
[[Category: Viral protein-rna complex]] | |||
Revision as of 12:40, 18 March 2020
Dimeric structure of Machupo virus polymerase bound to vRNA promoterDimeric structure of Machupo virus polymerase bound to vRNA promoter
Structural highlights
Function[Q6IVU0_MACHU] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836] |
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