5b6y: Difference between revisions
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==A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 36.2 us after photoexcitation== | ==A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 36.2 us after photoexcitation== | ||
<StructureSection load='5b6y' size='340' side='right' caption='[[5b6y]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='5b6y' size='340' side='right'caption='[[5b6y]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5b6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B6Y FirstGlance]. <br> | <table><tr><td colspan='2'>[[5b6y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halsa Halsa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B6Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B6Y FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 5b6y" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5b6y" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Halsa]] | [[Category: Halsa]] | ||
[[Category: Large Structures]] | |||
[[Category: Arima, T]] | [[Category: Arima, T]] | ||
[[Category: Iwata, S]] | [[Category: Iwata, S]] | ||
Revision as of 11:47, 11 March 2020
A three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 36.2 us after photoexcitationA three dimensional movie of structural changes in bacteriorhodopsin: structure obtained 36.2 us after photoexcitation
Structural highlights
Function[BACR_HALSA] Light-driven proton pump. Publication Abstract from PubMedBacteriorhodopsin (bR) is a light-driven proton pump and a model membrane transport protein. We used time-resolved serial femtosecond crystallography at an x-ray free electron laser to visualize conformational changes in bR from nanoseconds to milliseconds following photoactivation. An initially twisted retinal chromophore displaces a conserved tryptophan residue of transmembrane helix F on the cytoplasmic side of the protein while dislodging a key water molecule on the extracellular side. The resulting cascade of structural changes throughout the protein shows how motions are choreographed as bR transports protons uphill against a transmembrane concentration gradient. A three-dimensional movie of structural changes in bacteriorhodopsin.,Nango E, Royant A, Kubo M, Nakane T, Wickstrand C, Kimura T, Tanaka T, Tono K, Song C, Tanaka R, Arima T, Yamashita A, Kobayashi J, Hosaka T, Mizohata E, Nogly P, Sugahara M, Nam D, Nomura T, Shimamura T, Im D, Fujiwara T, Yamanaka Y, Jeon B, Nishizawa T, Oda K, Fukuda M, Andersson R, Bath P, Dods R, Davidsson J, Matsuoka S, Kawatake S, Murata M, Nureki O, Owada S, Kameshima T, Hatsui T, Joti Y, Schertler G, Yabashi M, Bondar AN, Standfuss J, Neutze R, Iwata S Science. 2016 Dec 23;354(6319):1552-1557. doi: 10.1126/science.aah3497. PMID:28008064[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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