6itf: Difference between revisions
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==Icosahedral asymmetric unit (iASU) model of the less refined, coarse part of FHV eluted particle== | ==Icosahedral asymmetric unit (iASU) model of the less refined, coarse part of FHV eluted particle== | ||
< | <SX load='6itf' size='340' side='right' viewer='molstar' caption='[[6itf]], [[Resolution|resolution]] 4.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6itf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Fhv Fhv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITF FirstGlance]. <br> | <table><tr><td colspan='2'>[[6itf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Fhv Fhv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ITF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ITF FirstGlance]. <br> | ||
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[[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). | [[http://www.uniprot.org/uniprot/CAPSD_FHV CAPSD_FHV]] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, 240 calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma. Peptide gamma: membrane-permeabilizing peptide produced by virus maturation, thereby creating the infectious virion. After endocytosis into the host cell, peptide gamma is probably exposed in endosomes, where it permeabilizes the endosomal membrane, facilitating translocation of viral capsid or RNA into the cytoplasm (Probable). | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Fhv]] | [[Category: Fhv]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
Revision as of 01:10, 7 March 2020
Icosahedral asymmetric unit (iASU) model of the less refined, coarse part of FHV eluted particleIcosahedral asymmetric unit (iASU) model of the less refined, coarse part of FHV eluted particle
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