1aoo: Difference between revisions

Revision as of 10:31, 2 May 2008

AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE

OverviewOverview

3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%.

About this StructureAbout this Structure

1AOO is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

3D solution structure of copper and silver-substituted yeast metallothioneins., Peterson CW, Narula SS, Armitage IM, FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:8566237 Page seeded by OCA on Fri May 2 10:31:20 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1aoo.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1aoo |SIZE=350|CAPTION= <scene name='initialview01'>1aoo</scene>
+The line below this paragraph, containing "STRUCTURE_1aoo", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=AG:SILVER+ION'>AG</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1aoo|  PDB=1aoo  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoo OCA], [http://www.ebi.ac.uk/pdbsum/1aoo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aoo RCSB]</span>
-}}
 '''AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE'''
@@ Line 28: / Line 25: @@
 [[Category: Narula, S S.]]
 [[Category: Peterson, C W.]]
-[[Category: copper detoxification]]
+[[Category: Copper detoxification]]
-[[Category: metal-thiolate cluster]]
+[[Category: Metal-thiolate cluster]]
-[[Category: metallothionein]]
+[[Category: Metallothionein]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:31:20 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:33 2008''