1aoc: Difference between revisions
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'''JAPANESE HORSESHOE CRAB COAGULOGEN''' | '''JAPANESE HORSESHOE CRAB COAGULOGEN''' | ||
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[[Category: Oganessyan, V.]] | [[Category: Oganessyan, V.]] | ||
[[Category: Typke, D.]] | [[Category: Typke, D.]] | ||
[[Category: | [[Category: Clottable protein]] | ||
[[Category: | [[Category: Coagulation factor]] | ||
[[Category: | [[Category: Cystine knot superfamily]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:30:29 2008'' | |||
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Revision as of 10:30, 2 May 2008
JAPANESE HORSESHOE CRAB COAGULOGEN
OverviewOverview
The clotting cascade system of the horseshoe crab (Limulus) is involved in both haemostasis and host defence. The cascade results in the conversion of coagulogen, a soluble protein, into an insoluble coagulin gel. The clotting enzyme excises the fragment peptide C from coagulogen, giving rise to aggregation of the monomers. The crystal structure of coagulogen reveals an elongated molecule that embraces the helical peptide C fragment. Cleavage and removal of the peptide C would expose an extended hydrophobic cove, which could interact with the hydrophobic edge of a second molecule, leading to a polymeric fibre. The C-terminal half of the coagulogen molecule exhibits a striking topological similarity to the neurotrophin nerve growth factor (NGF), providing the first evidence for a neurotrophin fold in invertebrates. Similarities between coagulogen and Spatzle, the Drosophila ligand of the receptor Toll, suggest that the neurotrophin fold might be considered more ancient and widespread than previously realized.
About this StructureAbout this Structure
1AOC is a Single protein structure of sequence from Tachypleus tridentatus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a coagulogen, the clotting protein from horseshoe crab: a structural homologue of nerve growth factor., Bergner A, Oganessyan V, Muta T, Iwanaga S, Typke D, Huber R, Bode W, EMBO J. 1996 Dec 16;15(24):6789-97. PMID:9003754 Page seeded by OCA on Fri May 2 10:30:29 2008