Sculpting protein conformations: Difference between revisions
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Sometimes it is instructive to change the conformation of a protein model. Typically this means "sculpting" an experimentally-determined (empirical) model into a hypothetical conformation with some functional significance<ref name="transition-paths">PMID:31435895</ref>. Here are described software packages that enable this to be done manually, using the mouse to drag portions of the original model into desired conformations. | Sometimes it is instructive to change the conformation of a protein model. Typically this means "sculpting" an experimentally-determined (empirical) model into a hypothetical conformation with some functional significance<ref name="transition-paths">PMID:31435895</ref>. Here are described software packages that enable this to be done manually, using the mouse to drag portions of the original model into desired conformations. | ||
As you sculpt a protein model, you are morphing it into a new conformation. However, [[Morphs|molecular morphing]] usually means saving a movie or animation that shows interpolated transitioning between two earlier-saved conformations, which may be empirical or theoretical. There are [[Morphs|many examples of molecular morphs]] in Proteopedia. Slides explaining how to morph a sculpted protein are available at [http://tinyurl.com/sculpting-proteins tinyurl.com/sculpting-proteins]. | As you sculpt a protein model, you are morphing it into a new conformation in real time. However, [[Morphs|molecular morphing]] usually means saving a movie or animation that shows interpolated transitioning between two earlier-saved conformations, which may be empirical or theoretical. There are [[Morphs|many examples of molecular morphs]] in Proteopedia. Slides explaining how to morph a sculpted protein are available at [http://tinyurl.com/sculpting-proteins tinyurl.com/sculpting-proteins]. | ||