2dea: Difference between revisions
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==Crystal Structure of the Aminopeptidase of Aeromonas proteolytica at pH 4.7== | ==Crystal Structure of the Aminopeptidase of Aeromonas proteolytica at pH 4.7== | ||
<StructureSection load='2dea' size='340' side='right' caption='[[2dea]], [[Resolution|resolution]] 1.24Å' scene=''> | <StructureSection load='2dea' size='340' side='right'caption='[[2dea]], [[Resolution|resolution]] 1.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_proteolytica"_merkel_et_al._1964 "aeromonas proteolytica" merkel et al. 1964]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DEA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aeromonas_proteolytica"_merkel_et_al._1964 "aeromonas proteolytica" merkel et al. 1964]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DEA FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[Aminopeptidase|Aminopeptidase]] | *[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Aeromonas proteolytica merkel et al. 1964]] | [[Category: Aeromonas proteolytica merkel et al. 1964]] | ||
[[Category: Bacterial leucyl aminopeptidase]] | [[Category: Bacterial leucyl aminopeptidase]] | ||
[[Category: Large Structures]] | |||
[[Category: Desmarais, W]] | [[Category: Desmarais, W]] | ||
[[Category: Petsko, G A]] | [[Category: Petsko, G A]] | ||
Revision as of 10:35, 4 March 2020
Crystal Structure of the Aminopeptidase of Aeromonas proteolytica at pH 4.7Crystal Structure of the Aminopeptidase of Aeromonas proteolytica at pH 4.7
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe aminopeptidase from Aeromonas proteolytica (AAP) contains two zinc ions in the active site and catalyzes the degradation of peptides. Herein we report the crystal structures of AAP at 0.95-A resolution at neutral pH and at 1.24-A resolution at low pH. The combination of these structures allowed the precise modeling of atomic positions, the identification of the metal bridging oxygen species, and insight into the physical properties of the metal ions. On the basis of these structures, a new putative catalytic mechanism is proposed for AAP that is likely relevant to all binuclear metalloproteases. The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica.,Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:16596389[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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