6t7y: Difference between revisions

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'''Unreleased structure'''


The entry 6t7y is ON HOLD until Paper Publication
==Structure of PCNA bound to cPIP motif of DP2 from P. abyssi==
 
<StructureSection load='6t7y' size='340' side='right'caption='[[6t7y]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6t7y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6T7Y FirstGlance]. <br>
Description:  
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6t7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t7y OCA], [http://pdbe.org/6t7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6t7y RCSB], [http://www.ebi.ac.uk/pdbsum/6t7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6t7y ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PCNA_PYRAB PCNA_PYRAB]] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317]<ref>PMID:22431731</ref>  
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Large Structures]]
[[Category: Beaufet, I Hugonneau]]
[[Category: Carroni, M]]
[[Category: Delarue, M]]
[[Category: Madru, C]]
[[Category: Raia, P]]
[[Category: Sauguet, L]]
[[Category: Dp2]]
[[Category: Pcna]]
[[Category: Pip-box]]
[[Category: Pold]]
[[Category: Replication]]

Revision as of 09:52, 4 March 2020

Structure of PCNA bound to cPIP motif of DP2 from P. abyssiStructure of PCNA bound to cPIP motif of DP2 from P. abyssi

Structural highlights

6t7y is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:DNA-directed DNA polymerase, with EC number 2.7.7.7
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[PCNA_PYRAB] Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non-specific cleavage.[HAMAP-Rule:MF_00317][1]

References

  1. ↑ Creze C, Ligabue A, Laurent S, Lestini R, Laptenok SP, Khun J, Vos MH, Czjzek M, Myllykallio H, Flament D. Modulation of the Pyrococcus abyssi NucS endonuclease activity by replication clamp at functional and structural levels. J Biol Chem. 2012 May 4;287(19):15648-60. doi: 10.1074/jbc.M112.346361. Epub 2012, Mar 19. PMID:22431731 doi:http://dx.doi.org/10.1074/jbc.M112.346361

6t7y, resolution 2.70Å

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