1alx: Difference between revisions

Revision as of 10:25, 2 May 2008

GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)

OverviewOverview

The linear pentadecapeptide antibiotic gramicidin D is a heterogeneous mixture of six components. Precise refinements of three-dimensional structures of naturally occurring gramicidin D in crystals obtained from methanol, ethanol, and n-propanol demonstrate the unexpected presence of stable left-handed antiparallel double-helical heterodimers that vary with the crystallization solvent. The side chains of Trp residues in the three structures exhibit sequence-specific patterns of conformational preference. Tyr substitution for Trp at position 11 appears to favor beta ribbon formation and stabilization of the antiparallel double helix that acts as a template for gramicidin folding and nucleation of different crystal forms. The fact that a minor component in a heterogeneous mixture influences aggregation and crystal nucleation has potential applications to other systems in which anomalous behavior is exhibited by aggregation of apparently homogeneous materials, such as the enigmatic behavior of prion proteins.

About this StructureAbout this Structure

Full crystallographic information is available from OCA.

ReferenceReference

Heterodimer formation and crystal nucleation of gramicidin D., Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL, Biophys J. 1998 Nov;75(5):2135-46. PMID:9788907 Page seeded by OCA on Fri May 2 10:25:58 2008

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OCA

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 [[Image:1alx.gif|left|200px]]
- {{Structure
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+The line below this paragraph, containing "STRUCTURE_1alx", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>
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-|GENE=
+-->
-|DOMAIN=
+{{STRUCTURE_1alx|  PDB=1alx  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alx OCA], [http://www.ebi.ac.uk/pdbsum/1alx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1alx RCSB]</span>
-}}
 '''GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)'''
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 ==About this Structure==
-ALX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALX OCA].
+Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALX OCA].
 ==Reference==
 Heterodimer formation and crystal nucleation of gramicidin D., Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL, Biophys J. 1998 Nov;75(5):2135-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9788907 9788907]
-[[Category: Brevibacillus brevis]]
-[[Category: Protein complex]]
 [[Category: Burkhart, B M.]]
 [[Category: Courseille, C.]]
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 [[Category: Precigoux, G.]]
 [[Category: Smith, G D.]]
-[[Category: peptide antibiotic]]
+[[Category: Peptide antibiotic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 10:25:58 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:57 2008''