5ayo: Difference between revisions

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-'''Unreleased structure'''
-The entry 5ayo is ON HOLD
+==Crystal structure of a bacterial homologue of iron transporter ferroportin in inward-facing state==
+<StructureSection load='5ayo' size='340' side='right'caption='[[5ayo]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5ayo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdeba Bdeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AYO FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aym|5aym]], [[5ayn|5ayn]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">slc39, Bd2019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ayo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ayo OCA], [http://pdbe.org/5ayo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ayo RCSB], [http://www.ebi.ac.uk/pdbsum/5ayo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ayo ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In vertebrates, the iron exporter ferroportin releases Fe(2+) from cells into plasma, thereby maintaining iron homeostasis. The transport activity of ferroportin is suppressed by the peptide hormone hepcidin, which exhibits upregulated expression in chronic inflammation, causing iron-restrictive anaemia. However, due to the lack of structural information about ferroportin, the mechanisms of its iron transport and hepcidin-mediated regulation remain largely elusive. Here we report the crystal structures of a putative bacterial homologue of ferroportin, BbFPN, in both the outward- and inward-facing states. Despite undetectable sequence similarity, BbFPN adopts the major facilitator superfamily fold. A comparison of the two structures reveals that BbFPN undergoes an intra-domain conformational rearrangement during the transport cycle. We identify a substrate metal-binding site, based on structural and mutational analyses. Furthermore, the BbFPN structures suggest that a predicted hepcidin-binding site of ferroportin is located within its central cavity. Thus, BbFPN may be a valuable structural model for iron homeostasis regulation by ferroportin.
-Authors: Taniguchi, R., Kato, H.E., Font, J., Deshpande, C.N., Ishitani, R., Jormakka, M., Nureki, O.
+Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin.,Taniguchi R, Kato HE, Font J, Deshpande CN, Wada M, Ito K, Ishitani R, Jormakka M, Nureki O Nat Commun. 2015 Oct 13;6:8545. doi: 10.1038/ncomms9545. PMID:26461048<ref>PMID:26461048</ref>
-Description: Crystal structure of a metal transporter
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 5ayo" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bdeba]]
+[[Category: Large Structures]]
+[[Category: Deshpande, C N]]
+[[Category: Font, J]]
+[[Category: Ishitani, R]]
+[[Category: Jormakka, M]]
+[[Category: Kato, H E]]
 [[Category: Nureki, O]]
-[[Category: Jormakka, M]]
-[[Category: Kato, H.E]]
 [[Category: Taniguchi, R]]
-[[Category: Deshpande, C.N]]
+[[Category: Alpha helical]]
-[[Category: Ishitani, R]]
+[[Category: Transport protein]]
-[[Category: Font, J]]