6ji4: Difference between revisions

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'''Unreleased structure'''


The entry 6ji4 is ON HOLD  until Feb 20 2021
==brd4-bd1 bound with ligand 138==
 
<StructureSection load='6ji4' size='340' side='right'caption='[[6ji4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
Authors: Cao, D.Y., Li, Y.L., Du, Z.Y., Li, J., Xiong, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6ji4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JI4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JI4 FirstGlance]. <br>
Description: brd4-bd1 bound with ligand 138
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOF:(3R)-4-cyclopropyl-1,3-dimethyl-6-[5-methyl-4-(4-methylphenyl)-4H-1,2,4-triazol-3-yl]-3,4-dihydroquinoxalin-2(1H)-one'>BOF</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ji4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ji4 OCA], [http://pdbe.org/6ji4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ji4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ji4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ji4 ProSAT]</span></td></tr>
[[Category: Cao, D.Y]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Cao, D Y]]
[[Category: Du, Z Y]]
[[Category: Li, J]]
[[Category: Li, Y L]]
[[Category: Xiong, B]]
[[Category: Xiong, B]]
[[Category: Du, Z.Y]]
[[Category: Bromodomain-containing protein 4]]
[[Category: Li, J]]
[[Category: Dna damage]]
[[Category: Li, Y.L]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

Revision as of 12:12, 26 February 2020

brd4-bd1 bound with ligand 138brd4-bd1 bound with ligand 138

Structural highlights

6ji4 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

References

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

6ji4, resolution 1.60Å

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OCA
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