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| </StructureSection> | | </StructureSection> |
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| == 3D Structures of thrombin==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''Thrombin'''
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|
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| **[[3r3g]], [[3gic]] - hThr HC + LC - human<br />
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| **[[3jz1]], [[3jz2]], [[2od3]] - hThr HC + LC (mutant) <br />
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| **[[3qgn]], [[4rkj]], [[5jdu]], [[6pxq]], [[6pxj], [[3ee0]], [[2a0q]], [[1sg8]], [[1sgi]], [[1jou]] - hThr HC (mutant) + LC<br />
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| **[[2hnt]]– hThr-γ HC + LC<br />
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| **[[3pmb]] - bThr HC + LC – bovine<br />
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| **[[2ocv]] - mThr HC + LC - mouse<br />
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| **[[3edx]], [[3hk3]], [[3hk6]] - mThr HC (mutant) + LC<br />
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|
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| *Thrombin complexes with small molecule
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|
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| **[[1bhx]], [[1abj]], [[1ppb]] - hThr HC + LC + inhibitor<br />
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| **[[4rn6]] - hThr HC (mutant) + inhibitor<br />
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| **[[3dd2]] - hThr HC + LC + RNA<br />
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| **[[1hao]], [[1hap]], [[1hut]] - hThr HC + LC + DNA<br />
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| **[[3bf6]] - hThr HC + LC + suramin<br />
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| **[[1xmn]] - hThr HC + LC + heparin<br />
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| **[[2h9t]] - hThr HC + LC + suramin + PPACK<BR />
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| **[[1z8i]], [[1z8j]] - hThr HC + LC (mutant) + PPACK<BR />
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| **[[1sfq]], [[1shh]], [[2thf]], [[1thp]], [[1b7x]], [[4rko]] - hThr HC (mutant) + LC + PPACK<BR />
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| **[[1ook]] - hThr HC + LC + PPACK<BR />
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| **[[2hpp]], [[2hpq]] - hThr HC + LC + PThr residues 214-292 + PPACK<BR />
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| **[[3pma]] – bThr HC + LC residues 336-364 + sucrose octasulfate<br />
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| **[[1uvs]], [[1uvt]], [[1uvu]] - bThr HC + LC + inhibitor<br />
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| **[[1etr]], [[1ets]], [[1ett]] – bThr-ε HC + LC + inhibitor<br />
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|
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| *Thrombin complexes with peptide
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|
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| **[[5gim]] - hPThr HC + LC + peptide<br />
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| **[[3hkj]] - hThr HC (mutant) + LC + proteinase-activated receptor 1 peptide<br />
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| **[[1fph]] - hThr HC + LC + fibrinogen peptide<br />
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| **[[3bv9]] - hThr HC (mutant) + LC + peptide inhibitor<br />
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| **[[2a2x]], [[1eb1]], [[1h8i]], [[1h8d]], [[1dit]], [[1hbt]], [[3u8t]] - hThr HC + LC + peptide inhibitor<br />
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| **[[1g37]], [[1eoj]], [[1eol]], [[1nrn]], [[1nro]], [[1nrp]], [[1nrq]], [[1nrr]], [[1nrs]] - hThr HC + peptide inhibitor<br />
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| **[[1hlt]] - hThr HC + LC + thrombomodulin peptide<br />
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| **[[4ch2]], [[4ch8]] - hThr HC + LC + platelet glycoprotein IB α chain peptide <br />
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| **[[2ank]], [[3po1]] - hThr HC + LC + peptide + inhibitor<br />
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| **[[1dlk]] - bThr HC + LC + peptide inhibitor<br />
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| **[[1ycp]], [[1bbr]] – bThr-ε HC + LC + fibrinogen peptide<br />
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| **[[1ucy]] - bThr HC + LC + fibrinogen peptide<br />
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| **[[3hki]] - mThr HC (mutant) + LC + proteinase-activated receptor 1 peptide<br />
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| **[[2pux]] - mThr HC + LC + proteinase-activated receptor 3 peptide<br />
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| **[[2pv9]] - mThr HC (mutant) + LC + proteinase-activated receptor 4 peptide<br />
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| **[[1dm4]] - mThr HC (mutant) + LC + fibrinogen peptide<br />
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|
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| *Thrombin complexes containing hirudin
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|
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| **[[3c27]], [[2zc9]], [[2zda]], [[2zdv]], [[3egk]], [[2r2m]], [[2v3h]], [[2v3o]], [[2pks]], [[3eq0]], [[3dt0]], [[3dux]], [[3da9]], [[3dhk]], [[2znk]], [[2zo3]], [[3d49]], [[2zhe]], [[2zhf]], [[2zhw]], [[2zg0]], [[2zfq]], [[2zfr]], [[2zhq]], [[2zi2]], [[2ziq]], [[2zff]], [[2zfp]], [[2zgb]], [[2zgx]], [[2zf0]], [[3biu]], [[3biv]], [[2uuj]], [[2uuk]], [[2jh0]], [[2jh5]], [[2jh6]], [[2gde]], [[2bxt]], [[2bxu]], [[2bvr]], [[2bvs]], [[2bvx]], [[2bdy]], [[2feq]], [[2c8w]], [[2c8x]], [[2c8y]], [[2c8z]], [[2c90]], [[2c93]], [[2cf8]], [[2cf9]], [[2anm]], [[2w7g]], [[2fes]], [[1ype]], [[1ypg]], [[1ypj]], [[1ypk]], [[1ypl]], [[1ypm]], [[1vzq]], [[1way]], [[1wbg]], [[1riw]], [[1mu6]], [[1mu8]], [[1mue]], [[1nzq]], [[1o0d]], [[1oyt]], [[1o2g]], [[1gj4]], [[1gj5]], [[1kts]], [[1ktt]], [[1ghv]], [[1ghw]], [[1ghx]], [[1ghy]], [[1c5n]], [[1c5o]], [[1c4y]], [[1d3d]], [[1d3p]], [[1d3q]], [[1d3t]], [[1c4u]], [[1c4v]], [[1c1u]], [[1c1v]], [[1c1w]], [[1qj1]], [[1qj6]], [[1qj7]], [[1qhr]], [[1qur]], [[1d4p]], [[1ba8]], [[1bb0]], [[1ca8]], [[1awf]], [[1awh]], [[1bcu]], [[1a61]], [[1a3b]], [[1a3e]], [[1a46]], [[1a5g]], [[1b5g]], [[1tbz]], [[1a4w]], [[1ay6]], [[1ae8]], [[1afe]], [[1ad8]], [[1ai8]], [[1aix]], [[1bmm]], [[1bmn]], [[1lhc]], [[1lhd]], [[1lhe]], [[1lhf]], [[1lhg]], [[1uma]], [[1aht]], [[1fpc]], [[1w7g]], [[3ldx]], [[3p17]], [[3qto]], [[3qtv]], [[3qwc]], [[3qx5]], [[3rlw]], [[3rly]], [[3rm0]], [[3rm2]], [[3rml]], [[3rmm]], [[3rmn]], [[3rmo]], [[3t5f]], [[3sv2]], [[3si3]], [[3si4]], [[3sha]], [[3shc]], [[3u98]], [[3u9a]], [[3uwj]], [[4e7r]], [[6eo8]], [[6eo9]], [[4loy]] - hThr HC + LC + hirudin peptide + inhibitor<br />
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| **[[1zgi]], [[1zgv]], [[1zrb]], [[1z71]], [[1xm1]], [[1sl3]], [[1ta2]], [[1ta6]], [[1nm6]], [[1nt1]], [[1doj]], [[1d9i]], [[1d6w]], [[1qbv]], [[1tmu]], [[1dwb]], [[1dwc]], [[1dwd]], [[1dwe]], [[4baq]], [[4bao]], [[4ban]], [[4bak]], [[4bam]], [[4bah]], [[5lpd]], [[5ahg]], [[5afz]], [[5afy]], [[5af9]], [[5a2m]], [[4yes]], [[4ufg]], [[4uff]], [[4ufe]], [[4ufd]], [[4ueh]], [[4ue7]], [[4udw]], [[4ud9]] - hThr HC + hirudin peptide + inhibitor<br />
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| **[[1ny2]], [[8kme]], [[7kme]], [[1a2c]], [[1tom]], [[1hdt]], [[1tmt]], [[1tmb]], [[3u8o]], [[3u8r]] - hThr HC + LC + hirudin peptide + peptide inhibitor<br />
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| **[[3hat]] - hThr HC + LC + hirudin peptide + fibrinogen peptide<br />
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| **[[2uuf]], [[2pw8]], [[1no9]], [[1c5l]], [[1vr1]], [[4thn]], [[5gds]], [[1hxf]], [[1hxe]], [[1abi]], [[1hgt]], [[1ihs]], [[1iht]], [[1thr]], [[1ths]], [[2hgt]], [[3utu]], [[4ayv]], [[4ayy]], [[4az2]], [[3htc]], [[4htc]] - hThr HC + LC + hirudin peptide<br />
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| **[[3vxe]], [[3vxf]] - hThr HC + LC + bivalirudin peptide<br />
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| **[[4mlf]] - hThr HC (mutant) + LC + hirudin peptide<br />
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| **[[5mm6]], [[5mls]], [[5mjt]] - hThr HC (mutant) + LC + hirudin peptide + inhibitor<br />
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| **[[1vit]], [[1hrt]] - bThr HC + LC + hirudin peptide<br />
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| *Thrombin complex with protein
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|
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| **[[2a45]] - hThr HC + LC + fibrinogen α, β, γ chains<br />
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| **[[1tb6]] - hThr HC + LC (mutant) + antithrombin<br />
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| **[[2b5t]] - hThr HC (mutant) + LC + antithrombin III (mutant)<br />
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| **[[4dt7]] - hThr HC (mutant) + LC + vitamin K-dependent protein C peptide<br />
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| **[[1jmo]] - hThr HC (mutant) + LC + heparin cofactor II<br />
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| **[[4dy7]] - hThr HC (mutant) + LC + glia-derived nexin<br />
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| **[[1e0f]] - hThr HC + LC + haemadin<br />
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| **[[4boh]] - hThr HC + LC + madanin<br />
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| **[[4e05]], [[4e06]] - hThr HC + LC + anophelin<br />
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| **[[1dx5]] - hThr HC + LC + thrombomodulin<br />
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| **[[3p6z]], [[3p70]] - hThr HC + LC + coagulation factor V<br />
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| **[[1de7]] - hThr HC + LC + factor XIII activation peptide<br />
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| **[[3pmh]] - hThr HC + LC + platelet glycoprotein IB α chain<br />
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| **[[3b23]] - hThr HC + LC + variegin<br />
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| **[[5e8e]] - hThr HC + LC + antibody<br />
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| **[[2a1d]], [[1nu7]] – bThr HC + LC + staphylocoagulase<br />
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| **[[1avg]] - bThr HC + LC + triabin<br />
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| **[[1bth]] - bThr HC (mutant) + LC (mutant) + BPTI<br />
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| **[[1toc]] - bThr HC + LC + ornithodorin<br />
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| **[[1tbq]], [[1tbr]] - bThr HC + LC + rhodniin<br />
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| *'''Prothrombin'''
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|
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| **[[3e6p]], [[2afq]], [[3u69]] - hPThr HC + LC<br />
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| **[[3s7h]], [[3s7k]]– hPThr HC + LC (mutant) <br />
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| **[[3bei]], [[2pgb]], [[2gp9]], [[1tq0]], [[1rd3]], [[4hzh]], [[4h6t]], [[4h6s]] - hPThr HC (mutant) + LC<br />
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| **[[1mh0]], [[4nzq]], [[4o03]] - hPThr HC (mutant) <br />
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| **[[1nl1]], [[1nl2]], [[2spt]], [[2pf1]], [[2pf2]] – bPThr residues 1-156
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|
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| *Prothrombin complexes
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| **[[3qdz]] – hPThr HC (mutant) + LC + proteinase-activated receptor 4 peptide<br />
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| **[[3lu9]], [[3bef]] - hPThr HC + LC (mutant) + proteinase-activated receptor 1 peptide<br />
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| **[[1sr5]] - hPThr HC + LC + antithrombin III<br />
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| **[[3k65]] - hPThr HC residues 315-622 (mutant) + LC residues 199-314<br />
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| **[[3f68]] - hPThr HC residues 364-622 + LC residues 328-363 + hirudin peptide<br />
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| **[[1jwt]], [[3c1k]] - hPThr HC + inhibitor<br />
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| **[[4hfp]] - hPThr HC (mutant) + LC + inhibitor<br />
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| **[[2pgq]], [[1tq7]] - hPThr HC (mutant) + LC + PPACK<BR />
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| **[[2cn0]], [[1t4u]], [[1t4v]], [[1sb1]], [[1k21]], [[1k22]], [[1g30]], [[1g32]], [[1o5g]], [[3tu7]], [[4lxb]], [[5lce]] - hPThr HC + LC + hirudin peptide + inhibitor<br />
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| **[[4ax9]] - hPThr HC + LC + hirudin peptide<br />
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| **[[1twx]] - hPThr HC (mutant) + LC + hirudin peptide<br />
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| **[[2hwl]] - hPThr HC (mutant) + LC + fibrinogen γ’ peptide<br />
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| **[[4i7y]], [[5ew2]], [[5ew1]], [[5cmx]] - hPThr HC + LC + DNA<br />
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| **[[5do4]] - hPThr HC + LC + RNA<br />
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|
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| *Prothrombin complex with protein
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|
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| **[[1id5]] - hPThr HC + LC + ecotin<br />
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| **[[1p8v]] - hPThr HC + LC + platelet glycoprotein IB α chain<br />
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| **[[3gis]] - hPThr HC residues 364-622 (mutant) + LC residues 315-363 + thrombomodulin<br />
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| **[[3b9f]] - hPThr HC (mutant) + LC + protein C inhibitor<br />
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| **[[2ody]] - hPThr HC + LC + boophilin<br />
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| **[[5nhu]] - hPThr HC + LC + CE5 anticoagulant<br />
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| **[[5l6n]] - hPThr HC + LC + madanin<br />
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| *'''Prethrombin-1'''
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|
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| **[[3nxp]] - hThr residues 199-622
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| *'''Prethrombin-2'''
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| **[[1nu9]] – hThr + staphylocoagulase<br />
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| **[[1mkw]], [[1mkx]] – hThr + bThr HC + LC<br />
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| **[[1hag]], [[1hah]] – hThr + hirudin peptide<br />
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| **[[1hai]] – hThr + inhibitor<br />
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| **[[3sqe]], [[3sqh]] - hThr (mutant)
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|
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| *'''Meizothrombin'''
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|
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| **[[1a0h]] - bMThr
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| }}
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| == References == | | == References == |