Flaps Morph for HIV Protease: Difference between revisions
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Here is shown a morph between a closed HIV protease and a "wide open" protease (<scene name='83/836583/Morph/2'>restore initial scene</scene>). (Note that "wide open" is not "fully open" -- see above.) | Here is shown a morph between a closed HIV protease and a "wide open" protease (<scene name='83/836583/Morph/2'>restore initial scene</scene>). (Note that "wide open" is not "fully open" -- see above.) | ||
<center>{{Template:Button_Toggle_Animation2}}</center> | <center>{{Template:Button_Toggle_Animation2}}</center> | ||
* Morph of ribbon/cartoon with flaps highlighted in <font color="orange">'''orange'''</font>. | * <scene name='83/836583/Morph/3'>Morph of ribbon/cartoon with flaps highlighted</scene> in <font color="orange">'''orange'''</font>. (Flaps: residues 42-58.) | ||
* Morph of spacefilling rendition with flaps highlighted in <font color="orange">'''orange'''</font>. | * <scene name='83/836583/Morph/4'>Morph of spacefilling rendition</scene> with flaps highlighted in <font color="orange">'''orange'''</font>. | ||
In the case of mutant [[1tw7]], about 100 water molecules reside in the active site, forming a hydrogen-bonded scaffold holding the flaps open<ref name="wide-open" />. | In the case of mutant [[1tw7]], about 100 water molecules reside in the active site, forming a hydrogen-bonded scaffold holding the flaps open<ref name="wide-open" />. | ||