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Flaps Morph for HIV Protease: Difference between revisions

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Eric Martz (talk | contribs)
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Eric Martz (talk | contribs)
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<StructureSection load='' size='350' side='right' caption='HIV protease: morph of flaps opening/closing ([[1hxw]] &harr; [[1tw7]]' scene='83/836583/Morph/1'>
<StructureSection load='' size='350' side='right' caption='HIV protease: morph of flaps opening/closing ([[1hxw]] &harr; [[1tw7]]).' scene='83/836583/Morph/1'>
The genome of HIV codes for synthesis of a polyprotein (UniProt [https://www.uniprot.org/uniprot/P04585 P04585 (POL_HV1H2)]) that requires cutting by HIV protease in order to be separated into individual mature proteins required for virus maturation<ref name="wide-open">PMID:16338417</ref>. Drugs that inhibit HIV protease prevent the virus from replicating, and are [[Molecular Playground/HIV Protease Inhibitor|crucial components of anti-HIV therapies]].
The genome of HIV codes for synthesis of a polyprotein (UniProt [https://www.uniprot.org/uniprot/P04585 P04585 (POL_HV1H2)]) that requires cutting by HIV protease in order to be separated into individual mature proteins required for virus maturation<ref name="wide-open">PMID:16338417</ref>. Drugs that inhibit HIV protease prevent the virus from replicating, and are [[Molecular Playground/HIV Protease Inhibitor|crucial components of anti-HIV therapies]].


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