4tn2: Difference between revisions
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==NS5b in complex with lactam-thiophene carboxylic acids== | ==NS5b in complex with lactam-thiophene carboxylic acids== | ||
<StructureSection load='4tn2' size='340' side='right' caption='[[4tn2]], [[Resolution|resolution]] 2.70Å' scene=''> | <StructureSection load='4tn2' size='340' side='right'caption='[[4tn2]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tn2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TN2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4tn2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_b_virus Hepatitis b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TN2 FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 4tn2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4tn2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[RNA-directed RNA polymerase|RNA-directed RNA polymerase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Hepatitis b virus]] | [[Category: Hepatitis b virus]] | ||
[[Category: Large Structures]] | |||
[[Category: Chopra, R]] | [[Category: Chopra, R]] | ||
[[Category: Complex polymerase inhbitor]] | [[Category: Complex polymerase inhbitor]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 11:17, 19 February 2020
NS5b in complex with lactam-thiophene carboxylic acidsNS5b in complex with lactam-thiophene carboxylic acids
Structural highlights
Publication Abstract from PubMedHerein we report the successful incorporation of a lactam as an amide replacement in the design of hepatitis C virus NS5B Site II thiophene carboxylic acid inhibitors. Optimizing potency in a replicon assay and minimizing potential risk for CYP3A4 induction led to the discovery of inhibitor 22a. This lead compound has a favorable pharmacokinetic profile in rats and dogs. Design and synthesis of lactam-thiophene carboxylic acids as potent hepatitis C virus polymerase inhibitors.,Barnes-Seeman D, Boiselle C, Capacci-Daniel C, Chopra R, Hoffmaster K, Jones CT, Kato M, Lin K, Ma S, Pan G, Shu L, Wang J, Whiteman L, Xu M, Zheng R, Fu J Bioorg Med Chem Lett. 2014 Aug 15;24(16):3979-85. doi:, 10.1016/j.bmcl.2014.06.031. Epub 2014 Jun 20. PMID:24986660[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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