6qlw: Difference between revisions

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-'''Unreleased structure'''
-The entry 6qlw is ON HOLD
+==Cathepsin-K in complex with MIV-710==
+<StructureSection load='6qlw' size='340' side='right'caption='[[6qlw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-Authors: Derbyshire, D.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qlw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QLW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QLW FirstGlance]. <br>
-Description: Cathepsin-K in complex with MIV-710
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=J5T:~{N}-[(2~{S})-1-[(3~{R},3~{a}~{R},6~{R},6~{a}~{S})-6-chloranyl-3-oxidanyl-2,3,3~{a},5,6,6~{a}-hexahydrofuro[3,2-b]pyrrol-4-yl]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-[5-fluoranyl-2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide'>J5T</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ql8|6ql8]]</td></tr>
-[[Category: Derbyshire, D.J]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qlw OCA], [http://pdbe.org/6qlw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qlw RCSB], [http://www.ebi.ac.uk/pdbsum/6qlw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qlw ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:[http://omim.org/entry/265800 265800]]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature.<ref>PMID:8703060</ref> <ref>PMID:9529353</ref> <ref>PMID:10491211</ref> <ref>PMID:10878663</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/CATK_HUMAN CATK_HUMAN]] Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cathepsin K]]
+[[Category: Large Structures]]
+[[Category: Derbyshire, D J]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor complex]]
+[[Category: Lysosomal cysteine proteinase]]