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Thioesterase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<scene name='48/489265/Cv/7'>Human ubiquitin esterase 2 complex with ubiquitin and zinc+2 ion</scene>. Ubiquitin thioesterase 2 active site contains the <scene name='48/489265/Cv/8'>catalytic triad Cys-His-Asn and the oxyanion hole Asn</scene>. The metal-binding enzyme contains a <scene name='48/489265/Cv/9'>Zn+2 ion which coordinates to 4 Cys residues</scene>. The <scene name='48/489265/Cv/10'>ubiquitin coordinates to the thioesterase via residues in all thioesterase domains: finger, palm and thumb</scene><ref>PMID:16905103</ref>.
<scene name='48/489265/Cv/7'>Human ubiquitin esterase 2 complex with ubiquitin and zinc+2 ion</scene>. Ubiquitin thioesterase 2 active site contains the <scene name='48/489265/Cv/8'>catalytic triad Cys-His-Asn and the oxyanion hole Asn</scene>. The metal-binding enzyme contains a <scene name='48/489265/Cv/9'>Zn+2 ion which coordinates to 4 Cys residues</scene>. The <scene name='48/489265/Cv/10'>ubiquitin coordinates to the thioesterase via residues in all thioesterase domains: finger, palm and thumb</scene><ref>PMID:16905103</ref>.
==3D structures of thioesterase==
[[Thioesterase 3D structures]]
</StructureSection>
</StructureSection>
==3D structures of thioesterase==
==3D structures of thioesterase==
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**[[3r34]] - ArTE (mutant) + CoA<br />
**[[3r34]] - ArTE (mutant) + CoA<br />
**[[6fdg]] – SaTE  – ''Staphylococcus aureus''<br />
**[[6fdg]] – SaTE  – ''Staphylococcus aureus''<br />
**[[5wh9]] – TE  – ''Bacillus halodurans''<br />


*Palmitoyl protein thioesterase
*Palmitoyl protein thioesterase


**[[3gro]] - hTEI - human<br />
**[[1pja]] – hTEII <br />
**[[1eh5]] – bTE1 + Palmitate – bovine<br />
**[[1eh5]] – bTE1 + Palmitate – bovine<br />
**[[1ei9]] – bTE1<br />
**[[1ei9]] – bTE1<br />
**[[1exw]] – bTE1 + hexadecylsulfonyl fluoride<br />
**[[1exw]] – bTE1 + hexadecylsulfonyl fluoride<br />
**[[1pja]] – hTEII – human<br />
**[[3gro]] - hTEI


*Acyl-CoA thioesterase
*Acyl-CoA thioesterase or acyl-CoA thioester hydrolase


**[[3hlk]] – hTE2<br />
**[[3k2i]] – hTE4<br />
**[[2qq2]] - hTE7 C terminal<br />
**[[3fo5]] – hTE11 START domain<br />
**[[3b7k]], [[4moc]] – hTE12<br />
**[[4mob]] – hTE12 + ADP<br />
**[[2v1o]] – mTE7 hotdog domain – mouse<br />
**[[2q2b]] – mTE7 C terminal<br />
**[[6vfy]] – mTE7 42-367 + acyl-CoA TE hydrolase + CoA<br />
**[[1tbu]] – TEI N terminal (peroximal) – yeast<br />
**[[2pzh]] - TE - ''Helicobacter pylori''<br />
**[[2pzh]] - TE - ''Helicobacter pylori''<br />
**[[3rd7]] – TE – ''Mycobacterium avium''<br />
**[[3rd7]] – TE – ''Mycobacterium avium''<br />
**[[5v3a]] – NmTE  + CoA + GDP – ''Neisseria meningitis''<br />
**[[5t02]] – NmTE (mutant)  + CoA + GDP <br />
**[[5hz4]], [[5hwf]], [[5egk]] – SaTE (mutant)  – ''Staphylococcus aureus''<br />
**[[5hz4]], [[5hwf]], [[5egk]] – SaTE (mutant)  – ''Staphylococcus aureus''<br />
**[[4egj]] – SaTE + CoA<br />
**[[4egj]] – SaTE + CoA<br />
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**[[1v2g]], [[1u8u]] - EcTEI + octanoic acid<br />
**[[1v2g]], [[1u8u]] - EcTEI + octanoic acid<br />
**[[5tid]], [[5tie]], [[5tif]] - EcTEI (mutant) + octanoic acid<br />
**[[5tid]], [[5tie]], [[5tif]] - EcTEI (mutant) + octanoic acid<br />
**[[1tbu]] – TEI N terminal (peroximal) – yeast<br />
**[[5tid]], [[5tie]], [[5tif]] - EcTEI (mutant) + octanoic acid<br />
**[[5t06]] - EcTEI (mutant) + hexanoyl-CoA<br />
**[[5t07]] - EcTEI (mutant) + decanoyl-CoA<br />
**[[1c8u]] – EcTEII <br />
**[[1c8u]] – EcTEII <br />
**[[3u0a]] – TEII – ''Mycobacterium marinum''<br />
**[[3u0a]] – TEII – ''Mycobacterium marinum''<br />
**[[4qfw]] – YpTE II – ''Yersinia pestis''<br />
**[[4qfw]] – YpTE II – ''Yersinia pestis''<br />
**[[4r4u]] – YpTE II + CoA<br />
**[[4r4u]] – YpTE II + CoA<br />
**[[3hlk]] – hTE2<br />
**[[5szv]], [[5szu]] – NmTE  + CoA – ''Neisseria meningitis''<br />
**[[3k2i]] – hTE4<br />
**[[5szz]], [[5szy]] – NmTE  + CoA + GDP<br />
**[[2qq2]] - hTE7 C terminal<br />
**[[5v3a]] – NmTE  + CoA + GDP <br />
**[[2v1o]] – mTE7 hotdog domain – mouse<br />
**[[5t02]] – NmTE (mutant)  + CoA + GDP <br />
**[[2q2b]] – mTE7 C terminal<br />
**[[3fo5]] – hTE11 START domain<br />
**[[3b7k]], [[4moc]] – hTE12<br />
**[[4mob]] – hTE12 + ADP<br />


*Acyl protein thioesterase
*Acyl protein thioesterase


**[[5sym]], [[6bje]] – hTE 1 + inhibitor<br />
**[[6qgs]] – hTE 1 + palmitate<br />
**[[6qgq]], [[6qgo]], [[6qgn]] – hTE 1 (mutant) + palmitate<br />
**[[5syn]] – hTE 2 + inhibitor<br />
**[[6avy]] – TE 2 - maize<br />
**[[1fj2]] – EcTEI<br />
**[[1fj2]] – EcTEI<br />
**[[6avy]] – TE 2 - maize<br />
**[[5sym]] – hTE 1 + inhibitor<br />
**[[5syn]] – hTE 2 + inhibitor<br />


*Acyl-ACP thioesterase
*Acyl-ACP thioesterase
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*Ubiquitin thioesterase 2
*Ubiquitin thioesterase 2


**[[2zfy]] – hUSP – human  <BR />
**[[2zfy]] – hUSP <BR />
**[[2hd5]], [[3nhe]], [[3v6c]], [[3v6e]] – hUSP + Ub  <BR />
**[[2hd5]], [[3nhe]], [[3v6c]], [[3v6e]] – hUSP + Ub  <BR />
**[[1tff]] – hUSP (mutant)  <BR />
**[[1tff]] – hUSP (mutant)  <BR />
**[[2ibi]] – hUSP (mutant) + Ub <BR />
**[[2ibi]], [[5xve]] – hUSP (mutant) + Ub <BR />
**[[5xu8]] – hUSP + Ub + thioguanine <BR />


*Ubiquitin thioesterase 3
*Ubiquitin thioesterase 3
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**[[2g43]], [[6dxh]], [[6dxt]] – hUSP zinc finger USP domain<br />
**[[2g43]], [[6dxh]], [[6dxt]] – hUSP zinc finger USP domain<br />
**[[2g45]] – hUSP zinc finger USP domain + Ub<br />
**[[2g45]] – hUSP zinc finger USP domain + Ub<br />
**[[6p9g]], [[6nft]] – hUSP zinc finger USP domain + quinazoline derivative<br />
**[[3ihp]] – hUSP + Ub  <BR />
**[[3ihp]] – hUSP + Ub  <BR />


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**[[1nbf]] – hUSP catalytic domain + Ub aldehyde<br />
**[[1nbf]] – hUSP catalytic domain + Ub aldehyde<br />
**[[5jtj]] – hUSP catalytic domain + polyubiquitin <br />
**[[5jtj]], [[5jtv]] – hUSP catalytic domain + polyubiquitin <br />
**[[5whc]], [[5n9r]], [[5n9t]], [[5uqv]], [[5uqx]], [[6f5h]] – hUSP catalytic domain + inhibitor<br />
**[[5whc]], [[5n9r]], [[5n9t]], [[5uqv]], [[5uqx]], [[6f5h]], [[5vsk]], [[5vsb]], [[5vs6]], [[5ngf]], [[5nge]] – hUSP catalytic domain + inhibitor<br />
**[[5kyc]], [[5kyd]], [[5kye]], [[5kyf]] – hUSP catalytic domain (mutant) + polyubiquitin <br />
**[[5kyc]], [[5kyd]], [[5kye]], [[5kyf]] – hUSP catalytic domain (mutant) + polyubiquitin <br />
**[[1yy6]] – hUSP TRAF domain + EBNA1 peptide<br />
**[[1yy6]] – hUSP TRAF domain + EBNA1 peptide<br />
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**[[2fop]] – hUSP TRAF domain + MDM2 peptide<br />
**[[2fop]] – hUSP TRAF domain + MDM2 peptide<br />
**[[4jjq]] – hUSP TRAF domain + E2 peptide<br />
**[[4jjq]] – hUSP TRAF domain + E2 peptide<br />
**[[5gg4]] – hUSP TRAF domain + E3 peptide<br />
**[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br />
**[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br />
**[[4ysi]], [[2foj]], [[2foo]] – hUSP TRAF domain + peptide<br />
**[[4ysi]], [[2foj]], [[2foo]] – hUSP TRAF domain + peptide<br />
**[[4yoc]], [[4z96]], [[4z97]] – hUSP residues 560-1102 + DNMT1<br />
**[[4yoc]], [[4z96]], [[4z97]] – hUSP residues 560-1102 + DNMT1<br />
**[[5c6d]] – hUSP residues 561-881 + UHRF1<br />
**[[5c6d]] – hUSP UBL2 domain + UHRF1<br />
**[[5c56]] – hUSP residues 560-1102 + Ub E3 ligase Icp0444w<br />
**[[5c56]] – hUSP residues 560-1102 + Ub E3 ligase Icp0444w<br />


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**[[2a9u]] – hUSP N terminal domain <br />
**[[2a9u]] – hUSP N terminal domain <br />
**[[2gfo]] – hUSP catalytic domain <br />
**[[2gfo]] – hUSP catalytic domain <br />
**[[3n3k]] – hUSP catalytic domain + ubiqitin<br />


*Ubiquitin thioesterase 8 complexes
*Ubiquitin thioesterase 8 complexes


**[[2gwf]] – hUSP rhodanase domain + ring finger protein 41 USP8 interaction domain<br />
**[[2gwf]] – hUSP rhodanase domain + ring finger protein 41 USP8 interaction domain<br />
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4f5k]], [[4fk5]] – yUSP + SUS1 + SGF11 +SGF73 <br />
**[[3n3k]] – hUSP catalytic domain + Ub<br />
**[[3mhs]] – yUSP + SUS1 + SGF11 +SGF73 + Ub<br />
**[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4f5k]], [[4fk5]], [[4wa6]] – yUSP + SUS1 + SGF11 +SGF73 <br />
**[[3mhs]], [[6aqr]] – yUSP + SUS1 + SGF11 +SGF73 + Ub<br />
**[[4zux]] – yUSP + SUS1 + SGF11 +SGF73 + Ub + Histones H3,2, H4, H2A, H2B + DNA<br />
**[[4zux]] – yUSP + SUS1 + SGF11 +SGF73 + Ub + Histones H3,2, H4, H2A, H2B + DNA<br />
**[[3n3k]] – hUSP catalytic domain + Ub<br />
 


*Ubiquitin thioesterase 9
*Ubiquitin thioesterase 9
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**[[4mel]] – hUSP DUSP+UBL domains <br />
**[[4mel]] – hUSP DUSP+UBL domains <br />
**[[5ok6]] – hUSP DUSP+UBL domains + peptide<br />
**[[4mem]] – rUSP DUSP+UBL domains - rat<br />
**[[4mem]] – rUSP DUSP+UBL domains - rat<br />


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*Ubiquitin thioesterase 14
*Ubiquitin thioesterase 14


**[[2ayn]] – hUSP catalytic domain<br />
**[[2ayo]] – hUSP catalytic domain + Ub aldehyde<br />
**[[6iin]], [[6iim]], [[6iil]], [[6iik]] – hUSP catalytic domain + inhibitor<br />
**[[5gjq]] – hUSP in proteasome – Cryo EM<br />
**[[1wiv]] – AtUSP UBA domain - NMR<br />
**[[1wgg]] – mUSP N terminal domain - NMR<br />
**[[1wgg]] – mUSP N terminal domain - NMR<br />
**[[2ayn]] – hUSP<br />
**[[2ayo]] – hUSP + Ub aldehyde<br />
**[[1wiv]] – AtUSP UBA domain - NMR<br />
**[[5gjq]] – hUSP in proteasome – Cryo EM<br />


*Ubiquitin thioesterase 15
*Ubiquitin thioesterase 15; domains – DUSP 1-133; UBL 134-223; catalytic 255-439+757-919


**[[3lmn]] – hUSP DUSP domain  <BR />
**[[3lmn]] – hUSP DUSP domain  <BR />
**[[1w6v]] – hUSP DUSP domain - NMR<br />
**[[3ppa]], [[3pv1]], [[3t9l]], [[4a3o]], [[4a3p]] – hUSP DUSP+UBL domains <br />
**[[3ppa]], [[3pv1]], [[3t9l]], [[4a3o]], [[4a3p]] – hUSP DUSP+UBL domains <br />
**[[1w6v]] – hUSP DUSP domain - NMR<br />
**[[6dj9]] – hUSP DUSP domain + Ub<BR />  
**[[5jjw]] – hUSP catalytic domain + SART HAT domain<br />
**[[6gha]] – hUSP catalytic domain <BR />
**[[5ctr]] – hUSP DUSP+UBL domains + SART HAT domain <br />
**[[5ctr]], [[5jjw]] – hUSP DUSP+UBL domains + SART HAT domain <br />
**[[6ml1]], [[6crn]], [[6cpm]] – hUSP catalytic domain + Ub <BR />
**[[6gh9]] – hUSP catalytic domain + quinone derivative <BR />


*Ubiquitin thioesterase 16
*Ubiquitin thioesterase 16
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*Ubiquitin thioesterase 18
*Ubiquitin thioesterase 18


**[[5cht]] – hUSP   <BR />
**[[5cht]] – mUSP  <BR />
**[[5chv]] – mUSP + Ub-like  <BR />
 
*USP 20
 
**[[6kcz]] – hUSP zinc finger + UBP domains - NMR  <BR />


*Ubiquitin thioesterase 21
*Ubiquitin thioesterase 21
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*Ubiquitin thioesterase 25
*Ubiquitin thioesterase 25


**[[5o71]] – hUSP <BR />
**[[6hem]], [[6h4k]] – hUSP C terminal  <BR />
**[[6hel]], [[6h4j]] – hUSP residues 157-714 <BR />
**[[1vdl]] – mUSP catalytic domain <br />
**[[1vdl]] – mUSP catalytic domain <br />


*Ubiquitin thioesterase 28
*Ubiquitin thioesterase 28;; domains – catalytic 149-399


**[[6hej]] – hUSP residues 149-703<BR />
**[[2lva]], [[2muu]], [[2mux]] – hUSP N terminal - NMR  <BR />
**[[2lva]], [[2muu]], [[2mux]] – hUSP N terminal - NMR  <BR />
**[[6h4i]] – hUSP catalytic domain <BR />
**[[6heh]] – hUSP catalytic domain (mutant)<BR />
**[[6hek]] – hUSP residues 149-703 + Ub  <BR />
**[[6hei]], [[6h4h]] – hUSP catalytic domain (mutant) + Ub  <BR />


*Ubiquitin thioesterase 30
*Ubiquitin thioesterase 30
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*Ubiquitin thioesterase 46
*Ubiquitin thioesterase 46


**[[5cvm]] – hUSP + Ub  <BR />
**[[5cvm]], [[5l8h]] – hUSP + Ub  <BR />
**[[5cvn]], [[5cvo]] – hUSP + WD repeat-containing protein + Ub<br />
**[[5cvn]], [[5cvo]] – hUSP + WDR48 + Ub<br />
**[[6jlq]] – hUSP + WDR48 + WDR20<br />


*Ubiquitin thioesterase Cyld
*Ubiquitin thioesterase Cyld
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**[[1uch]] – hUSP-L3  <br />
**[[1uch]] – hUSP-L3  <br />
**[[1xd3]] – hUSP-L3 + UBC<br />
**[[1xd3]] – hUSP-L3 + UBC<br />
**[[6isu]] – hUSP-L3 + Ub <br />
**[[2we6]] – PfUSP-L3 – ''Plasmodium falciparum''<br />
**[[2we6]] – PfUSP-L3 – ''Plasmodium falciparum''<br />
**[[2wdt]] – PfUSP-L3 + Ub <br />
**[[2wdt]] – PfUSP-L3 + Ub <br />
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**[[4uel]] – hUSP-L5 + polyUb + proteasomal Ub receptor Deubad domain  <br />
**[[4uel]] – hUSP-L5 + polyUb + proteasomal Ub receptor Deubad domain  <br />
**[[4uem]] – hUSP-L5 + proteasomal Ub receptor Deubad domain  <br />
**[[4uem]] – hUSP-L5 + proteasomal Ub receptor Deubad domain  <br />
**[[4uf5]], [[4wlp]] – hUSP-L5 + nuclear factor Deubad domain  <br />
**[[4uf6]] – hUSP-L5 + polyUb + nuclear factor Deubad domain  <br />
**[[4wlq]] – mUSP-L5 + proteasomal Ub receptor C terminal  <br />
**[[4wlq]] – mUSP-L5 + proteasomal Ub receptor C terminal  <br />
**[[4wlr]] – mUSP-L5 + polyUb + proteasomal Ub receptor C terminal  <br />
**[[4wlr]] – mUSP-L5 + polyUb + proteasomal Ub receptor C terminal  <br />
**[[4uf5]], [[4wlp]] – hUSP-L5 + nuclear factor Deubad domain  <br />
**[[4uf6]] – hUSP-L5 + polyUb + nuclear factor Deubad domain  <br />


*Ubiquitin thioesterase ZranB1
*Ubiquitin thioesterase ZranB1
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**[[4boz]] - hUSP OTU domain (mutant) + Ub <BR />
**[[4boz]] - hUSP OTU domain (mutant) + Ub <BR />
**[[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR />
**[[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR />
**[[4fjv]] - hUSP OTUB2 + Ub <BR />
**[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
**[[4dhi]] – nUSP + E2 <BR />
**[[4dhi]] – nUSP + E2 <BR />
**[[2kzr]] – mUSP UBX-like domain – NMR<br />
**[[2kzr]] – mUSP UBX-like domain – NMR<br />
**[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
**[[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br />
**[[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br />
**[[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR />
**[[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR />
*USP OTUB2
**[[5qiz]], [[5qiy]], [[5qix]], [[5qiw]], [[5qiu]], [[5qiv]], [[5qis]], [[5qit]], [[5qio]], [[5qip]], [[5qiq]], [[5qir]] – hUSP OTUB2 + ligand <BR />
**[[4fjv]] - hUSP OTUB2 + Ub <BR />
*USP OTULIN; Domains – OUT 80-345
**[[6i9c]] – hUSP OTU domain (mutant) <BR />
**[[5oe7]] – hUSP OUT domain + Ub <BR />
**[[6sak]] – hUSP OUT domain (mutant) + sorting nexin-27<BR />


*Ubiquitin thioesterase  
*Ubiquitin thioesterase  
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**[[5vpj]] – TE – ''Actinomadura verrucosospora''<br />
**[[5vpj]] – TE – ''Actinomadura verrucosospora''<br />
**[[5dio]], [[5byu]] – TE – ''Legionella pneumophila''<br />
**[[5dio]], [[5byu]] – TE – ''Legionella pneumophila''<br />
**[[6fvj]] – TE – ''Mycobacterium tuberculosis''<br />


}}
}}

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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