1aie: Difference between revisions
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'''P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE''' | '''P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE''' | ||
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[[Category: Gruetter, M G.]] | [[Category: Gruetter, M G.]] | ||
[[Category: Mittl, P R.E.]] | [[Category: Mittl, P R.E.]] | ||
[[Category: | [[Category: Dna]] | ||
[[Category: | [[Category: Oligomer]] | ||
[[Category: | [[Category: P53 tetramerization]] | ||
[[Category: | [[Category: Transcription]] | ||
[[Category: | [[Category: Tumor suppressor]] | ||
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Revision as of 10:18, 2 May 2008
P53 TETRAMERIZATION DOMAIN CRYSTAL STRUCTURE
OverviewOverview
The molecular replacement method is a powerful technique for crystal structure solution but the use of NMR structures as templates often causes problems. In this work the NMR structure of the p53 tetramerization domain has been used to solve the crystal structure by molecular replacement. Since the rotation- and translation-functions were not sufficiently clear, additional information about the symmetry of the crystal and the protein complex was used to identify correct solutions. The three-dimensional structure of residues 326-356 was subsequently refined to a final R factor of 19.1% at 1.5 A resolution.
About this StructureAbout this Structure
1AIE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystallization and structure solution of p53 (residues 326-356) by molecular replacement using an NMR model as template., Mittl PR, Chene P, Grutter MG, Acta Crystallogr D Biol Crystallogr. 1998 Jan 1;54(Pt 1):86-9. PMID:9761820 Page seeded by OCA on Fri May 2 10:18:30 2008