262d: Difference between revisions
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==A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS== | ==A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS== | ||
<StructureSection load='262d' size='340' side='right' caption='[[262d]]' scene=''> | <StructureSection load='262d' size='340' side='right'caption='[[262d]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=262D FirstGlance]. <br> | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=262D FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Theoretical Model]] | [[Category: Theoretical Model]] | ||
[[Category: Large Structures]] | |||
[[Category: Cedergren, R J]] | [[Category: Cedergren, R J]] | ||
[[Category: Ellington, A D]] | [[Category: Ellington, A D]] | ||
[[Category: Leclerc, F]] | [[Category: Leclerc, F]] | ||
Revision as of 08:16, 13 February 2020
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A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTSA THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS
Structural highlights
Publication Abstract from PubMedCoordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others. A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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