6umg: Difference between revisions

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-'''Unreleased structure'''
-The entry 6umg is ON HOLD  until Paper Publication
+==Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor==
+<StructureSection load='6umg' size='340' side='right'caption='[[6umg]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6umg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UMG FirstGlance]. <br>
-Description:
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6umh|6umh]], [[6umi|6umi]], [[6umj|6umj]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6umg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umg OCA], [http://pdbe.org/6umg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6umg RCSB], [http://www.ebi.ac.uk/pdbsum/6umg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6umg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RAMP1_HUMAN RAMP1_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.<ref>PMID:9620797</ref>  [[http://www.uniprot.org/uniprot/CALRL_HUMAN CALRL_HUMAN]] Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:22102369</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mohr, C]]
+[[Category: Class b gpcr]]
+[[Category: Complex]]
+[[Category: Fragment antigen binding]]
+[[Category: Membrane protein-immune system complex]]