6u3p: Difference between revisions

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'''Unreleased structure'''


The entry 6u3p is ON HOLD  until Paper Publication
==Binary complex of native hAChE with oxime reactivator LG-703==
 
<StructureSection load='6u3p' size='340' side='right'caption='[[6u3p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Kovalevsky, A., Gerlits, O., Radic, Z.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6u3p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3P FirstGlance]. <br>
Description: Binary complex of native hAChE with oxime reactivator LG-703
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PQY:(2E,2E)-N,N-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide]'>PQY</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3p OCA], [http://pdbe.org/6u3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3p RCSB], [http://www.ebi.ac.uk/pdbsum/6u3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3p ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acetylcholinesterase]]
[[Category: Large Structures]]
[[Category: Gerlits, O]]
[[Category: Gerlits, O]]
[[Category: Kovalevsky, A]]
[[Category: Radic, Z]]
[[Category: Radic, Z]]
[[Category: Kovalevsky, A]]
[[Category: Bis-oxime]]
[[Category: Hydrolase]]
[[Category: Reactivator complex]]

Revision as of 07:28, 13 February 2020

Binary complex of native hAChE with oxime reactivator LG-703Binary complex of native hAChE with oxime reactivator LG-703

Structural highlights

6u3p is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Acetylcholinesterase, with EC number 3.1.1.7
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ACES_HUMAN] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.[1] [2] [3] [4]

References

  1. ↑ Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989 Apr 24;247(2):279-82. PMID:2714437
  2. ↑ Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991 Dec 15;266(35):23977-84. PMID:1748670
  3. ↑ Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, et al.. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem. 1992 Sep 5;267(25):17640-8. PMID:1517212
  4. ↑ Yang L, He HY, Zhang XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res. 2002 Apr;42(4):261-8. PMID:11985878

6u3p, resolution 3.00Å

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