6nvf: Difference between revisions

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'''Unreleased structure'''


The entry 6nvf is ON HOLD  until Paper Publication
==Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8==
 
<StructureSection load='6nvf' size='340' side='right'caption='[[6nvf]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
Authors: Thompson, A.P., Polyak, S.W., Wegener, K.L., Bruning, J.B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6nvf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NVF FirstGlance]. <br>
Description: Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L5A:(4-{[(1S,2S)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5A</scene>, <scene name='pdbligand=L5J:(4-{[(1R,2R)-2-(carboxymethyl)cyclopentyl]methyl}phenyl)acetic+acid'>L5J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6cve|6cve]]</td></tr>
[[Category: Polyak, S.W]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dethiobiotin_synthase Dethiobiotin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.3 6.3.3.3] </span></td></tr>
[[Category: Bruning, J.B]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nvf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nvf OCA], [http://pdbe.org/6nvf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nvf RCSB], [http://www.ebi.ac.uk/pdbsum/6nvf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nvf ProSAT]</span></td></tr>
[[Category: Thompson, A.P]]
</table>
[[Category: Wegener, K.L]]
== Function ==
[[http://www.uniprot.org/uniprot/BIOD_MYCTU BIOD_MYCTU]] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.<ref>PMID:20565114</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Dethiobiotin synthase]]
[[Category: Large Structures]]
[[Category: Bruning, J B]]
[[Category: Polyak, S W]]
[[Category: Thompson, A P]]
[[Category: Wegener, K L]]
[[Category: Enzyme]]
[[Category: Ligase]]
[[Category: Nucleotide triphosphate binding]]
[[Category: Synthetase]]
[[Category: Transferase]]

Revision as of 07:16, 13 February 2020

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8

Structural highlights

6nvf is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Dethiobiotin synthase, with EC number 6.3.3.3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.[1]

References

  1. ↑ Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

6nvf, resolution 1.99Å

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