Syntaxin: Difference between revisions

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</StructureSection>
</StructureSection>


==3D structures of syntaxin==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Syntaxin 1
**[[2xhe]] – Stx1 + Unc18 – ''Monosiga brevicollis''<br />
*Syntaxin 1A; domains: N-terminal 1-150; SNARE motif 190-264
**[[1ez3]] – rStx1a N-terminal – rat<br />
**[[1br0]] – rStx1a N-terminal (mutant) – NMR<br />
**[[1hvv]] – rStx1a SNARE motif<br />
**[[2m8r]] – rStx1a SNARE motif - NMR<br />
**[[1jth]] – rStx1a SNARE motif + SNAP25<br />
**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
**[[6mti]] – rStx1a SNARE motif + synaptotagmin C2A+C2B domains + VAMP2 + SNAP25 – Cryo EM<br />
**[[6ip1]] – rStx1a + NAPA + VAMP2 + SNAP25 – Cryo EM<br />
**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
**[[5kj7]], [[5kj8]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP3 <br />
**[[2n1t]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR<br />
**[[5w5c]], [[5w5d]] – rStx1a SNARE motif + SNAP25 + VAMP2 + synaptotagmin + complexin-1<br />
**[[3c98]], [[4jeh]], [[4jeu]] – rStx1a + Unc18 <br />
**[[3j96]], [[3j97]], [[3j98]], [[3j99]], [[6mdm]], [[6mdn]] – rStx17 SNARE motif + SNAP25 + rVAMP2 + vesicle fusion ATPase + SNAP–α – Cryo EM<br />
*Syntaxin 6
**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
**[[1lvf]] – rStx6 N-terminal <br />
*Syntaxin 7
**[[1gl2]] – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse <br />
*Syntaxin 10
**[[4dnd]] – hStx10 <br />
*Syntaxin 12
**[[2dnx]] – hStx12 N-terminal - NMR<br />
*Syntaxin 13
**[[2nps]] – rStx13 SNARE motif + VAMP4 + hStx6 SNARE motif + VTI1-RP2 <br />
*Syntaxin 17
**[[4wy4]] – rStx17 SNARE motif + SNAP29 + VAMP8<br />
*s-syntaxin
**[[1s94]] – LpStx Habc domain – Loligo pealei<br />
**[[1l4a]] – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A<br />
*Syntaxin VAM3
**[[1hs7]] – Stx N-terminal – yeast - NMR<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 14:29, 12 February 2020


Function

Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane[1]. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs[2].

Relevance

The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor[3].

Structural highlights

(PDB code 3hd7). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions[4]. (PDB code 3ipd).

3D structures of syntaxin

Syntaxin 3D structures


Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  2. ↑ Liang B, Kiessling V, Tamm LK. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A. 2013 Nov 11. PMID:24218570 doi:http://dx.doi.org/10.1073/pnas.1314699110
  3. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  4. ↑ Stein A, Weber G, Wahl MC, Jahn R. Helical extension of the neuronal SNARE complex into the membrane. Nature. 2009 Jul 23;460(7254):525-8. Epub 2009 Jul 1. PMID:19571812 doi:10.1038/nature08156

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Michal Harel, Alexander Berchansky
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