Succinate Dehydrogenase: Difference between revisions

Since succinate dehydrogenase possesses multiple active sites that catalyze two different reactions, two classes of inhibitors function on the enzyme. The first class, which includes succinate analogs--both naturally-occuring TCA cycle intermediates like malate and oxaloacetate and the synthetic analog, malonate--contains some of the strongest succinate dehydrogenase inhibitors. The second class of inhibitors, which includes the ubiquinone analogs thenoyltrifluoroacetone and carboxin, binds to the ubiquinone active site and prevents reduction of the substrate<ref>PMID:17916065</ref>.

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==3D structures of succinate dehydrogenase==

*Succinate dehydrogenase quaternary complexes

**[[2wdv]] - EcSDH flavoprotein + Fe-S protein + cytochrome B-556 + membrane anchor protein subunits – ''Escherichia coli''<br />

**[[6c12]] - EcSDH flavoprotein + FAD assembly factor Sdhe<br />

**[[2wp9]] - EcSDH flavoprotein + Fe-S protein (mutant) + cytochrome B-556 + membrane anchor protein subunits<br />

**[[2ws3]], [[2wu2]], [[2wu5]] - EcSDH flavoprotein + Fe-S protein + cytochrome B-556 + membrane anchor protein subunits (mutant)<br />

**[[3abv]], [[3ae1]], [[3ae2]], [[3ae3]], [[3ae4]], [[3ae5]], [[3ae6]], [[3ae7]], [[3ae8]], [[3ae9]], [[3aea]], [[3aeb]], [[3aec]], [[3aed]], [[3aeg]], [[4ytp]] - pSDH flavoprotein + Fe-S protein + cytochrome B subunits +  benzamide derivative<br />

**[[2fbw]], [[2wqy]] - cSDH flavoprotein + IP + cytochrome B subunits + carboxin<br />

**[[2h89]] - cSDH flavoprotein + IP + cytochrome B subunits + malonate<br />

**[[4ysx]] - prSDH flavoprotein + Fe-S protein + cytochrome B subunits + inhibitor<br />

**[[4ysy]], [[4ysz]], [[4yt0]], [[4ytm]], [[4ytn]] - prSDH flavoprotein + Fe-S protein + cytochrome B subunits +  benzamide derivative<br />

**[[5c3j]], [[5c2t]] - prSDH flavoprotein + Fe-S protein + cytochrome B subunits +  ubiquinone derivative<br />

  }}

==References==

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