Stathmin: Difference between revisions
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== Disease == | == Disease == | ||
Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. | Decreased levels of STM-4 are found in brains of adults with Down syndrome and Alzheimer disease<ref>PMID:11771751</ref>. | ||
== 3D Structures of stathmin-4 == | |||
[[Stathmin-4 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br /> | **[[3hkd]] – rSTM + tubulin + GTP + GDP + pyrrolidine derivative <br /> | ||
**[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br /> | **[[3hke]] – rSTM + tubulin + GTP + GDP + benzenesulfonamide derivative <br /> | ||
**[[6h9b]] – rSTM + tubulin + GTP + GDP + quinoline derivative <br /> | |||
*Stathmin SLD domain complex with tubulin and drugs | *Stathmin SLD domain complex with tubulin and drugs | ||
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**[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br /> | **[[4iij]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP <br /> | ||
**[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br /> | **[[4ihj]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP <br /> | ||
**[[5jqg]], [[6i5c]], [[4i55]], [[5xp3]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br /> | **[[5jqg]], [[6i5c]], [[4i55]], [[5xp3]], [[6jcj]], [[6gze] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative <br /> | ||
**[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]], [[5o7a]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br /> | **[[5yl2]], [[5ylj]], [[5yls]], [[6br1]], [[6brf]], [[6bry]], [[6bs2]], [[6d88]], [[6fkj]], [[6fkl]], [[5o7a]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + inhibitor <br /> | ||
**[[5ov7]] – rSTM + tubulin + protein + GTP + GDP + ACP + inhibitor<br /> | |||
**[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br /> | **[[5xkf]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + inhibitor<br /> | ||
**[[4o2a]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br /> | **[[4o2a]], [[6k9vj]], [[6o5m]], [[6o5n]], [[6o61]], [[6qqn]], [[6agk]], [[5z4u]], [[5z4p]], [[5xi7]], [[5xi5]], [[5xhc]], [[5h7o]], [[6qtn]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ADP + inhibitor<br /> | ||
**[[6hx8]], [[6eg5]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + quinoline derivative<br /> | |||
**[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br /> | **[[5lov]], [[5njh]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + azoamide<br /> | ||
**[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br /> | **[[5lxs]], [[5lxt]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + discodermolide<br /> | ||
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**[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug<br /> | **[[5xke]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-gout drug<br /> | ||
**[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br /> | **[[4o2b]] – rSTM + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-gout drug<br /> | ||
**[[5xkh]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br /> | **[[5xkh]], [[5h74]], [[5gon]], [[5ezy]] – rSTM-4 + tubulin + protein + GTP + GDP + anti-cancer drug<br /> | ||
**[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]], [[4i50]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br /> | **[[4o4l]], [[5j2t]], [[5bmv]], [[5la6]], [[5jh7]], [[5jvd]], [[5fnv]], [[5c8y]], [[5ca0]], [[5ca1]], [[5cb4]], [[4yj2]], [[4yj3]], [[4x1i]], [[4x1k]], [[4x1y]], [[4x20]], [[4tuy]], [[4zol]], [[4tv8]], [[4tv9]], [[4o4j]], [[4o4l]], [[5i50]], [[4i4t]], [[4o4i]], [[4o2l]], [[5iyz]], [[5la6]], [[5m7e]], [[5m7g]], [[5m8d]], [[5m8g]], [[5xlt]], [[5yl4]], [[5xkg]], [[5xlt]], [[6fii]], [[6fjf]], [[6fjm]], [[5xlz]], [[4i50]], [[6knzj]], [[6n47]], [[6nng]], [[6gj4]], [[6gf3]], [[6f7c]], [[5zxh]], [[5yz3]], [[5xag]], [[5xaf]], [[5osk]], [[5ng1]], [[5nfz]], [[5jcb]] – rSTM-4 + tubulin + tubulin tyrosine ligase + GTP + GDP + ATP derivative + anti-cancer drugs<br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||