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| == Function == | | == Function == |
| Polyamines are essential in all branches of life. '''Spermidine synthase''' (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine<ref>PMID:17585781</ref>. SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine. | | Polyamines are essential in all branches of life. '''Spermidine synthase''' (putrescine aminopropyltransferase, PAPT) (SPS) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine<ref>PMID:17585781</ref>. SPS catalyzes the transfer of aminopropyl group from decarboxylated S-adenosylmethionine (SAM) to the amine acceptor spermidine. N4-Bis(aminopropyl) spermidine synthase of branched-chain polyamine synthase is an aminopropyltransferase essential for synthesis of branched-chain polyamines which enables thermophiles to grow in high temperature environments<ref>PMID:24610711</ref>. |
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| == Disease == | | == Disease == |
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| </StructureSection> | | </StructureSection> |
| ==3D structures of spermidine synthase==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Spermidine synthase
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| **[[2o05]], [[2o06]], [[2o07]], [[2o0l]] – SPS – human<br />
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| **[[1inl]] – TmSPS – ''Thermotoga maritima''<br />
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| **[[1mjf]] – SPS – ''Pyrococcus furiosus''<br />
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| **[[2e5w]], [[2zsu]] - SPS – ''Pyrococcus horikishii''<br />
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| **[[1iy9]] – SPS – ''Bacillus subtilis''<br />
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| **[[1xj5]], [[2q41]], [[6o63]] – AtSPS 1 – ''Arabidopsis thaliana''<br />
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| **[[6o64]] – AtSPS 2<br />
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| **[[2b2c]] – SPS – ''Caenorhabditis elegans''<br />
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| **[[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br />
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| **[[2pss]] – PfSPS – ''Plasmodium falciparum''<br />
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| **[[3o4f]] – SPS – ''Escherichia coli''<br />
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| **[[3bwb]] - TcSPS – ''Trypanosoma cruzi''<br />
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| *Binary complexes of spermidine synthase
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| **[[3rw9]] - hSPS + SAH<br />
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| **[[6o65]] – AtSPS 1 + SAM<br />
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| **[[1jq3]] – TmSPS + transition state analog<br />
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| **[[2hte]], [[2pt6]] - PfSPS + methylthioadenosine <br />
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| **[[2i7c]] - PfSPS + transition state analog<br />
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| **[[2pwp]] - PfSPS + spermidine<br />
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| **[[3b7p]] - PfSPS + spermine<br />
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| **[[6i1n]], [[6hy1]] – PfSPS + cyclohexane derivative<br />
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| **[[3bwc]] - TcSPS + SAM <br />
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| **[[3anx]] – TtSPS + methylthioadenosine – ''Thermus thermophilus''<br />
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| *Ternary complexes of spermidine synthase
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| **[[3c6k]], [[4cxm]], [[4uoe]] - hSPS + methylthioadenosine + spermidine<br />
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| **[[3c6m]] - hSPS + methylthioadenosine + spermine<br />
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| **[[2pt6]], [[3rie]], [[4bp3]], [[4bp1]] - PfSPS + inhibitor + methylthioadenosine<br />
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| **[[2pt9]] - PfSPS + inhibitor + SAM derivative<br />
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| **[[4cwa]], [[5b1s]] - PfSPS + inhibitor + ethanol derivative<br />
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| **[[4yv0]], [[4yv1]], [[4yv2]], [[4yuv]], [[4yuw]], [[4yux]], [[4yuy]], [[4yuz]] - TcSPS + inhibitor + SAM derivative<br />
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| *N(4) – Bis(aminopropyl) spermidine synthase or branched-chain polyamine synthase
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| **[[5xnf]] – TkBPSA – ''Thermococcus kodakarensis''<br />
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| **[[5xnh]] – TkBPSA + spermidine <br />
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| **[[5xnc]], [[6j26]] – TkBPSA + N4-aminopropylspermidine + methylthioadenosine <br />
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| **[[6j27]] – TtBPSA + N4-aminopropylspermidine + methylthioadenosine <br />
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| **[[6j28]] – TtBPSA (mutant) + N4-aminopropylspermidine + methylthioadenosine <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. | | Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |