6px6: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6px6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6px6 OCA], [http://pdbe.org/6px6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6px6 RCSB], [http://www.ebi.ac.uk/pdbsum/6px6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6px6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6px6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6px6 OCA], [http://pdbe.org/6px6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6px6 RCSB], [http://www.ebi.ac.uk/pdbsum/6px6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6px6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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== Publication Abstract from PubMed == | |||
The highly homologous human leukocyte antigen (HLA)-DQ2 molecules, HLA-DQ2.5 and HLA-DQ2.2, are implicated in the pathogenesis of celiac disease (CeD) by presenting gluten peptides to CD4(+) T cells. However, while HLA-DQ2.5 is strongly associated with disease, HLA-DQ2.2 is not, and the molecular basis underpinning this differential disease association is unresolved. We here provide structural evidence for how the single polymorphic residue (HLA-DQ2.5-Tyr22alpha and HLA-DQ2.2-Phe22alpha) accounts for HLA-DQ2.2 additionally requiring gluten epitopes possessing a serine at the P3 position of the peptide. In marked contrast to the biased T cell receptor (TCR) usage associated with HLA-DQ2.5-mediated CeD, we demonstrate with extensive single-cell sequencing that a diverse TCR repertoire enables recognition of the immunodominant HLA-DQ2.2-glut-L1 epitope. The crystal structure of two CeD patient-derived TCR in complex with HLA-DQ2.2 and DQ2.2-glut-L1 (PFSEQEQPV) revealed a docking strategy, and associated interatomic contacts, which was notably distinct from the structures of the TCR:HLA-DQ2.5:gliadin epitope complexes. Accordingly, while the molecular surfaces of the antigen-binding clefts of HLA-DQ2.5 and HLA-DQ2.2 are very similar, differences in the nature of the peptides presented translates to differences in responding T cell repertoires and the nature of engagement of the respective antigen-presenting molecules, which ultimately is associated with differing disease penetrance. | |||
A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease.,Ting YT, Dahal-Koirala S, Kim HSK, Qiao SW, Neumann RS, Lundin KEA, Petersen J, Reid HH, Sollid LM, Rossjohn J Proc Natl Acad Sci U S A. 2020 Jan 23. pii: 1914308117. doi:, 10.1073/pnas.1914308117. PMID:31974305<ref>PMID:31974305</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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== References == | |||
<references/> | |||
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</StructureSection> | </StructureSection> | ||