6jmx: Difference between revisions

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-'''Unreleased structure'''
-The entry 6jmx is ON HOLD  until Paper Publication
+==Structure of open form of peptidoglycan peptidase==
+<StructureSection load='6jmx' size='340' side='right'caption='[[6jmx]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jmx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"campylobacter_fetus_subsp._jejuni"_smibert_1974 "campylobacter fetus subsp. jejuni" smibert 1974]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JMX FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">A8118_01115 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=197 "Campylobacter fetus subsp. jejuni" Smibert 1974])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jmx OCA], [http://pdbe.org/6jmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jmx RCSB], [http://www.ebi.ac.uk/pdbsum/6jmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jmx ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Assembly of the peptidoglycan is crucial in maintaining viability of bacteria and in defining bacterial cell shapes, both of which are important for existence in the ecological niche that the organism occupies. Here, eight crystal structures for a member of the cell-shape-determining class of Campylobacter jejuni, the peptidoglycan peptidase 3 (Pgp3), are reported. Characterization of the turnover chemistry of Pgp3 reveals cell wall D,D-endopeptidase and D,D-carboxypeptidase activities. Catalysis is accompanied by large conformational changes upon peptidoglycan binding, whereby a loop regulates access to the active site. Furthermore, prior hydrolysis of the crosslinked peptide stem from the saccharide backbone of the peptidoglycan on one side is a pre-requisite for its recognition and turnover by Pgp3. These analyses reveal the noncanonical nature of the transformations at the core of the events that define the morphological shape for C. jejuni as an intestinal pathogen.
-Authors: Min, K.J., An, D.R., Yoon, H.J., Suh, S.W., Lee, H.H.
+Peptidoglycan reshaping by a noncanonical peptidase for helical cell shape in Campylobacter jejuni.,Min K, An DR, Yoon HJ, Rana N, Park JS, Kim J, Lee M, Hesek D, Ryu S, Kim BM, Mobashery S, Suh SW, Lee HH Nat Commun. 2020 Jan 23;11(1):458. doi: 10.1038/s41467-019-13934-4. PMID:31974386<ref>PMID:31974386</ref>
-Description: Structure of open form of peptidoglycan peptidase
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Min, K.J]]
+<div class="pdbe-citations 6jmx" style="background-color:#fffaf0;"></div>
-[[Category: Suh, S.W]]
+== References ==
-[[Category: Lee, H.H]]
+<references/>
-[[Category: Yoon, H.J]]
+__TOC__
-[[Category: An, D.R]]
+</StructureSection>
+[[Category: Campylobacter fetus subsp. jejuni smibert 1974]]
+[[Category: Large Structures]]
+[[Category: An, D R]]
+[[Category: Lee, H H]]
+[[Category: Min, K J]]
+[[Category: Suh, S W]]
+[[Category: Yoon, H J]]
+[[Category: Hydrolase]]
+[[Category: Peptidoglycan]]