Art:Molecular Sculpture: Difference between revisions

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An example illustrating the importance of models from Byron's Bender occurred at a scientific meeting in the mid 1970's. At this time, less than two dozen protein structures had been solved. David Davies brought a Bender model of an immunoglobulin Fab fragment, and Jane and David Richardson brought a Bender model of superoxide dismutase. While comparing these physical models at the meeting, they realized that both proteins use a similar fold, despite having only about 9% sequence identity. This incident<ref name="benderig">PMID: 1271464</ref> was the first recognition of the occurrence of what is now recognized as the immunoglobulin superfamily domain in proteins that are apparently unrelated by sequence.

Byron's Bender remained available through the 1990's. Tim Herman, then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.

Byron's Bender remained available through the 1990's. [[#Tim_Herman|Tim Herman]], then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.

Aside from the importance of the tactile as well as visual input these models provide, another of their great strengths is that they jiggle and vibrate when handled, thereby simulating thermal motion. Too often users of computer models lose sight of the fact that protein molecules in living systems are constantly flexing due to thermal motion.

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 An example illustrating the importance of models from Byron's Bender occurred at a scientific meeting in the mid 1970's. At this time, less than two dozen protein structures had been solved. David Davies brought a Bender model of an immunoglobulin Fab fragment, and Jane and David Richardson brought a Bender model of superoxide dismutase. While comparing these physical models at the meeting, they realized that both proteins use a similar fold, despite having only about 9% sequence identity. This incident<ref name="benderig">PMID: 1271464</ref> was the first recognition of the occurrence of what is now recognized as the immunoglobulin superfamily domain in proteins that are apparently unrelated by sequence.
-Byron's Bender remained available through the 1990's. Tim Herman, then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.
+Byron's Bender remained available through the 1990's. [[#Tim_Herman|Tim Herman]], then of the Medical College of Wisconsin (later he founded<ref name="3dmd" /><ref name="cbm" />) was one of its last avid users. Tim brought the Bender into local high schools and taught teachers and groups of students how to construct models.
 Aside from the importance of the tactile as well as visual input these models provide, another of their great strengths is that they jiggle and vibrate when handled, thereby simulating thermal motion. Too often users of computer models lose sight of the fact that protein molecules in living systems are constantly flexing due to thermal motion.