4ap8: Difference between revisions
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==Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)== | ==Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)== | ||
<StructureSection load='4ap8' size='340' side='right' caption='[[4ap8]], [[Resolution|resolution]] 2.78Å' scene=''> | <StructureSection load='4ap8' size='340' side='right'caption='[[4ap8]], [[Resolution|resolution]] 2.78Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP8 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AP8 FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Molybdopterin synthase]] | [[Category: Molybdopterin synthase]] | ||
[[Category: Allerston, C]] | [[Category: Allerston, C]] | ||
Revision as of 20:04, 29 January 2020
Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)
Structural highlights
Disease[MOC2B_HUMAN] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:252150]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry. Function[MOC2B_HUMAN] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.[1] [2] References
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