4ajf: Difference between revisions
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==Identification and structural characterization of PDE10 fragment inhibitors== | ==Identification and structural characterization of PDE10 fragment inhibitors== | ||
<StructureSection load='4ajf' size='340' side='right' caption='[[4ajf]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4ajf' size='340' side='right'caption='[[4ajf]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ajf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJF FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ajf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AJF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AJF FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[Phosphodiesterase|Phosphodiesterase]] | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Aharony, D]] | [[Category: Aharony, D]] | ||
[[Category: Akerud, T]] | [[Category: Akerud, T]] | ||
Revision as of 19:57, 29 January 2020
Identification and structural characterization of PDE10 fragment inhibitorsIdentification and structural characterization of PDE10 fragment inhibitors
Structural highlights
Function[PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.[1] See AlsoReferences |
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