4boe: Difference between revisions
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==Japanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal form== | ==Japanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal form== | ||
<StructureSection load='4boe' size='340' side='right' caption='[[4boe]], [[Resolution|resolution]] 2.24Å' scene=''> | <StructureSection load='4boe' size='340' side='right'caption='[[4boe]], [[Resolution|resolution]] 2.24Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4boe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brown_ear_tick Brown ear tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOE FirstGlance]. <br> | <table><tr><td colspan='2'>[[4boe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brown_ear_tick Brown ear tick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BOE FirstGlance]. <br> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Brown ear tick]] | [[Category: Brown ear tick]] | ||
[[Category: Large Structures]] | |||
[[Category: Austyn, J M]] | [[Category: Austyn, J M]] | ||
[[Category: Johnson, S]] | [[Category: Johnson, S]] | ||
Revision as of 19:52, 29 January 2020
Japanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal formJapanin from Rhipicephalus appendiculatus bound to cholesterol: Tetragonal crystal form
Structural highlights
Publication Abstract from PubMedTwo crystal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicephalus appendiculatus), have been determined at 2.2 and 2.4 A resolution. In both crystal forms the protein is in complex with cholesterol, which sits in a closed pocket at the centre of the lipocalin barrel. Both crystal forms are dimers, which are also observed in solution. Molecular modelling suggests that previously-described members of a tick protein family bearing high sequence homology to Japanin are also likely to bind cholesterol or cholesterol derivatives. Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks.,Roversi P, Johnson S, Preston SG, Nunn MA, Paesen GC, Austyn JM, Nuttall PA, Lea SM Sci Rep. 2017 Nov 22;7(1):16057. doi: 10.1038/s41598-017-16413-2. PMID:29167574[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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