6tb4: Difference between revisions
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==Structure of SAGA bound to TBP== | |||
<StructureSection load='6tb4' size='340' side='right'caption='[[6tb4]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6tb4]] is a 13 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Komagataella_phaffii_gs115 Komagataella phaffii gs115]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TB4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TB4 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tb4 OCA], [http://pdbe.org/6tb4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tb4 RCSB], [http://www.ebi.ac.uk/pdbsum/6tb4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tb4 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/C4QXP2_KOMPG C4QXP2_KOMPG]] Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.[PIRNR:PIRNR017246] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Komagataella phaffii gs115]] | |||
[[Category: Large Structures]] | |||
[[Category: Ben-Shem, A]] | [[Category: Ben-Shem, A]] | ||
[[Category: Crucifix, C]] | [[Category: Crucifix, C]] | ||
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[[Category: Papai, G]] | [[Category: Papai, G]] | ||
[[Category: Schultz, P]] | [[Category: Schultz, P]] | ||
[[Category: Histone-acetylation]] | |||
[[Category: Transcription]] | |||
[[Category: Transcriptional co-activator]] | |||
Revision as of 18:42, 29 January 2020
Structure of SAGA bound to TBPStructure of SAGA bound to TBP
Structural highlights
Function[C4QXP2_KOMPG] Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.[PIRNR:PIRNR017246] |
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