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The | ==The Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domains== | ||
<StructureSection load='6hw2' size='340' side='right'caption='[[6hw2]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6hw2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HW2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hw2 OCA], [http://pdbe.org/6hw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hw2 RCSB], [http://www.ebi.ac.uk/pdbsum/6hw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hw2 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CBX3_HUMAN CBX3_HUMAN]] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Hirsch, J A]] | |||
[[Category: Tanner, N]] | |||
[[Category: Tripathy, D R]] | |||
[[Category: Complex]] | |||
[[Category: Transport protein]] | |||
Revision as of 18:24, 29 January 2020
The Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domainsThe Crystal Structure of CaV beta4c in complex with HP1gamma chromo shadow domains
Structural highlights
Function[CBX3_HUMAN] Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
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