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==Crystal structure of vaborbactam bound to KPC-2== | |||
<StructureSection load='6td0' size='340' side='right'caption='[[6td0]], [[Resolution|resolution]] 0.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6td0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TD0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TD0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4D6:{(3R,6S)-2-HYDROXY-3-[(THIOPHEN-2-YLACETYL)AMINO]-1,2-OXABORINAN-6-YL}ACETIC+ACID'>4D6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6td0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6td0 OCA], [http://pdbe.org/6td0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6td0 RCSB], [http://www.ebi.ac.uk/pdbsum/6td0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6td0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BLKPC_KLEPN BLKPC_KLEPN]] Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Beta-lactamase]] | |||
[[Category: Large Structures]] | |||
[[Category: Hinchliffe, P]] | |||
[[Category: Spencer, J]] | |||
[[Category: Tooke, C L]] | |||
[[Category: Antimicrobial protein]] | |||
[[Category: Boronate]] | |||
[[Category: Inhibitor]] | |||
Revision as of 19:19, 22 January 2020
Crystal structure of vaborbactam bound to KPC-2Crystal structure of vaborbactam bound to KPC-2
Structural highlights
Function[BLKPC_KLEPN] Hydrolyzes carbapenems, penicillins, cephalosporins and monobactams with varying efficiency. |
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